Quantitative MRI of extra-ocular muscles in myasthenia gravis

eiden University Medical Center0 个研究点目标入组 130 人开始时间: 待定最近更新: 2024年6月11日

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•Recently diagnosed MG patients
•- Definitive diagnosis of MG defined as the presence of serum autoantibodies (anti—acetylcholine receptor [AChR],
•anti-muscle specific tyrosine kinase [MUSK])
•- Start of symptoms was less than a year ago
•- No corticosteroid treatment received in the past year
•- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction (T4, TSH), Chronic MG patients
•- Definitive diagnosis of MG, defined as described above
•- Persisting symptoms of diplopia
•- Start of symptoms was more than a year ago
•- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction (T4, TSH), Seronegative MG
•- Clinical diagnosis of MG with asymmetric, fluctuating and fatigable muscle weakness and at least one abnormal
•neurophysiological test, indicative of neuromuscular dysfunction (repetitive nerve stimulation or single fiber EMG)
•- No serum autoantibodies (anti—acetylcholine receptor [AChR], anti-muscle specific tyrosine kinase [MuSK])
•- No TSH-receptor auto-antibodies, no laboratory signs of thyroid dysfunction (T4, TSH)
•Healthy controls
•- No symptoms of diplopia
•- No ophthalmopathy
•- No prior systemic treatment with corticosteroids, Patient controls: Graves' orbitopathy
•- Definitive diagnosis of Graves' orbitopathy, Patient controls: Other neuromuscular disease
•- Definitive diagnosis of a neuromuscular disease other than Myasthenia gravis

•- Subjects who are not legally capable
•- Subjects under the age of 18
•- Contraindications to MRI scanning, including:
•o Claustrophobia
•o Pregnancy
•o Pacemakers and defibrillators
•o Nerve stimulators
•o Intracranial clips
•o Metallic fragments
•o Cochlear implants
•o Ferromagnetic implants
•o Hydrocephalus pump
•o Permanent make-up
•o Tattoos above the shoulders
•o Piercings (unless they can be removed)
•o Subjects who cannot keep their head still (eg. Tremor, Parkinson's disease)
•o Severe physical restriction (completely wheelchair dependent)
•? In the case of uncertainty about the MRI-contraindications, the MR-safety commission of the radiology
•department will decide whether this subject can be included in the study or not.

发起方

eiden University Medical Center