The use of clobazam and clonazepam in conjunction with other antiepileptics in the treatment of focal epilepsies: analysis of their efficacy and adverse effects
Not Applicable
Recruiting
- Conditions
- EpilepsyC10.228.140.490
- Registration Number
- RBR-4frcs6
- Lead Sponsor
- niversidade Federal de Pernambuco
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Diagnosis of focal epilepsy according to ILAE classification;
Focal epilepsy with at least 1 epileptic seizure every 2 months, in current use of monotherapy or polytherapy;
Age above 18 years;
Regularity and attendance at scheduled appointments.
Exclusion Criteria
Comorbidities such as severe kidney or liver disease that prevent the use of therapy proposed by the study;
Use one of two study drugs, namely clobazam or clonazepam.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It is expected to find a reduction of 50% or greater in the frequency of epileptic seizures in the patients of the two study groups in the medical interview of the third postoperative month, using a simple percentage calculation, namely number of seizures before less nu number of seizures after divided by the number of seizures before<br>;To analyze the rate of intervention interruption in any patient in the two study groups after 3 months due to the emergence of significant and / or disabling adverse effects, lack of efficacy, or both
- Secondary Outcome Measures
Name Time Method To assess the drug tolerability rate introduced to patients in the two study groups by the percentage calculation of drug discontinuation throughout the study