Mindfulness Intervention to Study the Neurobiology of Depression

Not Applicable

Completed

• Conditions: Depression
• Interventions: Behavioral: Rumination-Focused Cognitive Behavior Therapy

• Registration Number: NCT01905267
• Lead Sponsor: University of Illinois at Chicago

Brief Summary

The Pediatric Mood Disorders Program at the University of Illinois at Chicago is conducting a research study examining how mindfulness can help teenagers stay healthy and prevent depression relapse.

Detailed Description

Study involves:

* Brain scan using fMRI technology

* Questions about mood and behavior

* Meeting with a clinician

* Possibility of 8 weekly treatment sessions using mindfulness

* Ongoing assessment of depression for next 2 years

Eligible participants will be compensated for their time.

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-07-10
• Study First Submitted QC: 2013-07-18
• Study First Posted: 2013-07-23
• Primary Completion: 2017-06
• Study Completion: 2017-06
• Results First Submitted: 2017-08-03
• Status Verified: 2017-10
• Results First Submitted QC: 2017-10-25
• Last Update Submitted: 2017-10-25
• Results First Posted: 2018-07-30
• Last Update Posted: 2018-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• between the ages of 12 and 18
• history of major depressive disorder

Exclusion Criteria

• braces
• afraid of small spaces

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment	Rumination-Focused Cognitive Behavior Therapy	Participants randomized to the experimental condition will receive 8 weeks of individual treatment with Rumination-Focused Cognitive Behavior Therapy

Primary Outcome Measures

Name	Time	Method
Change in Children's Depression Rating Scale - Revised	Baseline, 8 week	clinician measure completed with adolescent and parent Total scores reported. Range is between 17-119 Higher scores mean higher depressive symptoms

Secondary Outcome Measures

Name	Time	Method
Change in Reynolds Adolescent Depression Scale	Baseline, 8 week	Self report adolescent depression total score. Range is 30-120 with higher scores meaning greater depressive symptoms.

Trial Locations

Locations (1)

University of Illinois at Chicago Pediatric Mood Disorders Program; 🇺🇸 Chicago, Illinois, United States