Mindfulness Intervention to Study the Neurobiology of Depression
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 33
- Locations
- 2
- Primary Endpoint
- Change in Children's Depression Rating Scale - Revised
Study Overview
Brief Summary
The Pediatric Mood Disorders Program at the University of Illinois at Chicago is conducting a research study examining how mindfulness can help teenagers stay healthy and prevent depression relapse.
Detailed Description
Study involves:
- Brain scan using fMRI technology
- Questions about mood and behavior
- Meeting with a clinician
- Possibility of 8 weekly treatment sessions using mindfulness
- Ongoing assessment of depression for next 2 years
Eligible participants will be compensated for their time.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 12 Years to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •between the ages of 12 and 18
- •history of major depressive disorder
Exclusion Criteria
- •afraid of small spaces
Arms & Interventions
Treatment
Participants randomized to the experimental condition will receive 8 weeks of individual treatment with Rumination-Focused Cognitive Behavior Therapy
Intervention: Rumination-Focused Cognitive Behavior Therapy (Behavioral)
Control
Participants randomized to the control arm will complete questionnaires and receive mood monitoring for the duration of the study
Outcomes
Primary Outcomes
Change in Children's Depression Rating Scale - Revised
Time Frame: Baseline, 8 week
clinician measure completed with adolescent and parent Total scores reported. Range is between 17-119 Higher scores mean higher depressive symptoms
Secondary Outcomes
- Change in Reynolds Adolescent Depression Scale(Baseline, 8 week)
Investigators
Rachel Jacobs
Research Assistant Professor, Licensed Clinical Psychologist
University of Illinois at Chicago