Investigating the Neuropsychological Mechanisms Underlying Mindfulness-based Cognitive Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 2
- 主要终点
- Changes in self-compassion following MBCT measured by both neuropsychological and self-report measures
研究概览
简要总结
This research will investigate the neuropsychological mechanisms underlying the eight-week Mindfulness-based Cognitive Therapy (MBCT) programme.
Participants in remission from depression will be seen pre- and post-MBCT to assess the underlying neuropsychological mechanisms. All will be followed-up over 12 months to assess the relationship of these neuropsychological changes with relapse risk.
The research will focus primarily on changes in self-compassion, rumination, attention and structural brain changes, with secondary focus on other mechanisms of emotional processing and memory.
详细描述
There will be three groups in total.
- The first group will take 36 participants in remission from major depression (rMDD) through the 8 week MBCT program.
- A control group of 36 rMDD participants will not receive the intervention.
- A group of never depressed healthy control participants will also be recruited.
Research visits for participants not undergoing MBCT will be separated by an 8 week gap.
All participants will be seen before and after the 8 weeks for completion of neuropsychological assessments and questionnaires.
rMDD participants will be followed up over the following 12 months to identify any predictors of relapse.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants with remitted depression (rMDD):
- •At least two previous episodes of DSM-IV major depression in adulthood, diagnosed using the Mini International Neuropsychiatric Interview (M.I.N.I).
- •Full or partial remission for at least three months with two depressive episodes within the last five years.
- •A score of less than or equal to 12 on the Montgomery Asberg Depression Rating Scale (MADRS) mood assessment.
- •If on medication, no recent or planned major changes
- •Healthy volunteers:
- •In good psychological health screened with the M.I.N.I
- •All participants:
- •in good physical health (to reduce risk of confounding physical health problems).
- •sufficiently fluent in English to ensure valid understanding and completion of the tasks.
- •minimum I.Q level of 80 to ensure sufficient understanding of the neurocognitive tasks administered.
- •colour vision and acuity within normal/corrected to normal limits.
- •Exclusion criteria:
- •Any current mental health diagnosis (DSM-IV diagnosis including current major depression, bipolar disorder, psychosis, Obsessive Compulsive Disorder (OCD), substance abuse or dependence, eating disorders)
- •Physical health or neurological disorders that might interfere with the interpretation of the tasks, including a history of significant head injury.
- •In addition healthy volunteers will be without a history mental health disorders (DSM-IV)
- •Current or previous experience of mindfulness-based treatments or extensive cognitive behavioural treatment, or planned participation in psychological treatments during the key time for the study (between pre and post visits).
- •Planned major alteration in drug treatment for depression between pre and post visits.
排除标准
- 未提供
研究组 & 干预措施
Mindfulness-based Cognitive Therapy
Individuals currently in remission from depression will choose to enter the Mindfulness-based Cognitive Therapy (MBCT) arm and undergo the 8 week MBCT group programme
干预措施: Mindfulness-based Cognitive Therapy (Behavioral)
Non-MBCT arm
Individuals currently in remission from depression will choose not to undergo the 8 week MBCT group programme
Healthy volunteers
Individuals who have never experienced major depression
结局指标
主要结局
Changes in self-compassion following MBCT measured by both neuropsychological and self-report measures
时间窗: measured at baseline and post intervention (8 weeks post baseline) and at each follow-up visit (3 in total)
Two neuropsychological measures of self-compassion have been developed and will be administerat baseline and after MBCT/8 week gap (8 weeks post baseline). Self-report questionnaires will be administered before and after MBCT/8 week gap and at subsequent follow-up visits (3, 6, 12 months).
次要结局
- Changes in levels of rumination following MBCT measured through both neuropsychological and self-report measures(measured at baseline and after the intervention/8 week gap (8 weeks post baseline) and at each follow-up visit (3 in total))
- Changes in attention regulation following MBCT(measured at baseline and after the intervention/8 week gap (8 weeks post baseline))
- Changes in brain structure following MBCT(measured at baseline and after the intervention (8 weeks post baseline))
研究者
Kate Williams
PhD Student
University of Manchester