跳至主要内容
临床试验/NCT01831362
NCT01831362已完成不适用

Dismantling Mindfulness: Contributions of Attention vs. Acceptance

Brown University2 个研究点 分布在 1 个国家目标入组 104 人开始时间: 2013年2月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
104
试验地点
2
主要终点
Change in Inventory of Depressive Symptomatology

研究概览

简要总结

This study addresses NCCAM's request for research that investigates the neuropsychological mechanisms underlying mind-body therapies, and for precise criteria and better delineation of meditation practices.

The purpose of this study is to assess the clinical efficacy and mechanism of action of 2 component practices of "mindfulness meditation", i.e. focused awareness (FA) and open monitoring (OM) in comparison to each other and to the standard package, Mindfulness-Based Cognitive Therapy (MBCT).

详细描述

Meditation, particularly mindfulness meditation, is one of the most popular Complementary and Alternative Medicine (CAM) therapies for alleviating emotional stress, depression and anxiety. While standardized meditation-based treatment packages like Mindfulness Based Stress Reduction (MBSR) and Mindfulness-based Cognitive Therapy (MBCT) have reliably shown sustained improvements in emotional disturbances and wellbeing, they contain so many different components and practices that the active ingredient cannot be ascertained. What is commonly called "Mindfulness" meditation is actually comprised of two separate practices: 1) focused awareness practice (FA), and 2) open-monitoring practice (OM). This project aims to create separate 8 week programs for FA and OM meditations, compare their clinical efficacy and investigate their separate mechanisms of action in individuals with clinically significant levels of persistent negative affect and depression. The clinical benefit and mechanism of action of focused awareness (FA) vs open-monitoring (OM) vs MBCT will be examined with a 3-armed randomized control trial of these 8 week interventions. Outcome variables include negative affect (depression, anxiety, stress) and wellbeing. Hypothesized mediating processes include objectively measured attention, emotion regulation and the basic wakefulness on which they depend.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Sequential
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • English-speaking
  • ages 18-65
  • mild-severe levels of depression or high level of negative affect

排除标准

  • age <18 or >65
  • inability to read and write in English
  • Extremely severe levels of depression
  • active suicidal ideation
  • presence of Axis I personality disorder
  • panic disorder
  • post-traumatic stress disorder
  • obsessive-compulsive disorder
  • eating disorder, or substance abuse/dependence
  • current psychotherapy
  • change in antidepressant medication type or dosage in the last 8 weeks.
  • Lifetime history exclusions:
  • bipolar disorder
  • psychotic disorders
  • persistent antisocial behavior or repeated self-harm,
  • borderline personality disorder,
  • organic brain damage
  • regular meditation practice

研究组 & 干预措施

Focused Attention (FA)

Experimental

This 8 week program consists solely of focused attention practices, i.e. selected attention to an object (breath etc) and deselection of other stimuli

干预措施: Focused Attention (FA) (Behavioral)

Open-Monitoring (OM)

Experimental

This 8-week program consists solely of open monitoring practices, or noticing and/or labeling the contents of ongoing experience ( thoughts, body sensations, emotions, seeing, hearing etc) without focusing on or deselecting any stimuli

干预措施: Open- Monitoring (Behavioral)

Mindfulness-Based Cognitive Therapy (MBCT)

Experimental

The 8 week MBCT program follows the 2nd Edition (2012) manual (Segal, Williams, Teasdale) and includes both focused attention and open- monitoring practices

干预措施: Mindfulness-Based Cognitive Therapy (Behavioral)

结局指标

主要结局

Change in Inventory of Depressive Symptomatology

时间窗: baseline, 8 weeks, 20 weeks

30-item clinician administered interview about unipolar depression symptoms

change in Depression, Anxiety Stress Scale (DASS)

时间窗: baseline, week 2,4,6,8, 20

42-item self-report questionnaire on depression, anxiety and stress symptoms

change in Wellbeing Scale (WBS)

时间窗: baseline, 8 weeks, 20 weeks

73-item self-report questionnaire of psychological wellbeing

次要结局

  • Sustained Attention to response Task (SART)(baseline, 8 weeks)
  • Difficulties in Emotion Regulation Scale (DERS)(baseline, 8 weeks, 20 weeks)
  • Attention Control Questionnaire (Derryberry & Reed, 2002)(baseline, 8 weeks, 20 weeks)
  • Change in Facial EMG power from baseline to 8 weeks(baseline and 8 weeks)
  • Change in alpha-theta EEG power from baseline to 8 weeks(baseline and 8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Willoughby Britton

Assistant Professor of Psychiatry and Human Behavior

Brown University

研究点 (2)

Loading locations...

相似试验