Sodium Alginate in Chocolate Milk, Satiety and Glycemic Control

Not Applicable

Completed

• Conditions: Health; Appetite Regulation; Glucose Metabolism
• Interventions: Other: Dietary intervention

• Registration Number: NCT01877460
• Lead Sponsor: University of Toronto

Brief Summary

This study compares the effects of isovolumetric (325 ml) preloads of chocolate milk supplemented with sodium alginates at incremental doses on inter-meal glucose levels, appetite scores and food intake in healthy adult men. The findings of this study will illustrate whether the addition of sodium alginate to chocolate milk will improve the glycemic properties of chocolate milk and will potentiate its satiating characteristics. This study will also elucidate whether sodium alginates, incorporated into chocolate milk, will influence glycemia, appetite sensations and food intake in a dose-dependent manner. It is hypothesized that there will be a synergy between milk and sodium alginate beyond either alone. When combined with milk components, sodium alginate is expected to improve glycemia and induce satiety more than does either milk alone or alginate alone.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2012-07
• Study Completion: 2012-07
• Status Verified: 2013-06
• Study First Submitted: 2013-06-06
• Study First Submitted QC: 2013-06-12
• Last Update Submitted: 2013-06-12
• Study First Posted: 2013-06-13
• Last Update Posted: 2013-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Healthy,
• non-smoking male subjects,
• aged 20-30 years with a body mass index between 20 and 24.9 kg/m2, were recruited.

Read More

Exclusion Criteria

• Breakfast skippers,
• smokers,
• dieters,
• individuals with lactose-intolerance or
• who are allergic to milk,
• individuals with gastrointestinal problems and
• individuals with diabetes or other metabolic diseases were excluded from the study.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
2.5% sodium alginate chocolate milk	Dietary intervention	Chocolate milk (Beatrice Ltd., Toronto, Ontario) with 2.5% sodium alginate
2.5% sodium alginate milk-free water-based solution	Dietary intervention	Water solution with 2.5% sodium alginate
Sodium alginate-free chocolate milk	Dietary intervention	Sodium alginate-free chocolate milk (1% fat) (Beatrice Ltd., Toronto, Ontario)
1.25% sodium alginate chocolate milk	Dietary intervention	Chocolate milk (Beatrice Ltd., Toronto, Ontario) with 1.25% sodium alginate

Primary Outcome Measures

Name	Time	Method
Satiety Change	0, 10, 20, 30, 45, 60, 75, 90 and 120 min (pre-meal) and 140, 170, 200, 230 and 260 min (post-meal) after consumption of the treatments	Pre-meal changes from 0 min; Post-meal changes from 120 min; Satiety scores (mm) were assessed using 100-mm "Motivation to Eat" visual analog scale questionnaires. A composite score of the four appetite questions, including Desire to Eat, Hunger, Fullness and Prospective Food Consumption, in the "Motivation to Eat" visual analog scale was calculated to obtain the average appetite score for statistical analysis.

Secondary Outcome Measures

Name	Time	Method
Food Intake	120 min	Food intake (kCal) was assessed 120 min after consumption of the treatments, using an ad libitum pizza lunch meal. Participants were asked to eat, during a 20-min period, until feeling comfortably full.

Trial Locations

Locations (1)

Department of Nutritional Sciences, FitzGerald Building; 🇨🇦 Toronto, Ontario, Canada