MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden

Completed

• Conditions: Acute Myocardial Infarction

• Registration Number: NCT01359033
• Lead Sponsor: University College, London

Brief Summary

The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.

Detailed Description

Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.

The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.

Study Timeline

• Study Start: 2011-03
• Study First Submitted: 2011-05-23
• Study First Submitted QC: 2011-05-23
• Study First Posted: 2011-05-24
• Primary Completion: 2013-12
• Status Verified: 2014-02
• Study Completion: 2014-12
• Last Update Submitted: 2017-11-14
• Last Update Posted: 2017-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 510863

Inclusion Criteria

• Patients aged above 30 years old who had hospital admission for acute myocardial infarction.
• Admission period ranged from 1st January, 2004 to 31th December, 2008.

Exclusion Criteria

• Patients with missing data in the admission time and/or primary outcomes.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
30-day mortality	30-day	all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction

Secondary Outcome Measures

Name	Time	Method
1-year mortality	1 year	all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction

Trial Locations

Locations (2)

Uppsala Clinial Research Center; 🇸🇪 Uppsala, Sweden

University College London; 🇬🇧 London, United Kingdom