Clinical, Radiographic and Histological/Histomorphometric Analysis of Maxillary Sinus Grafting With Deproteinized Porcine or Bovine Bone Mineral: a Randomized Controlled Clinical Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Histomorphometry
- Sponsor
- Camlog Oral Reconstruction Foundation
- Enrollment
- 30
- Primary Endpoint
- New bone formation
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The present study aimed to compare the histomorphometrically evaluated new bone formation, the radiographically measured graft stability and the clinical implant outcome between maxillary sinuses grafted either with deproteinized porcine bone mineral (DPBM) or deproteinized bovine bone mineral (DBBM). Conclusions: From a clinical point of view, the present results demonstrate that DPBM provides for comparable bone formation and stable graft dimension and high implant success rates combined with healthy peri-implant condition:
Detailed Description
Materials and Methods: Thirty maxillary sinuses in 28 participants were initially included and randomly assigned to the test group (TG;DPBM: n=15) or the control group (CG,DBBM: n=15). After a healing period (6 months) bone core biopsies were axially retrieved in the molar site for histological/ histomorphometrical analysis of new bone formations. In addition, radiographically measured graft stability as well as the clinical implant outcome (implant survival/success/peri-implant health) were assessed at the 1-year and 3-year follow-up evaluations.
Investigators
Krennmair Gerald
Univ.Prof.Dr.Dr
Camlog Oral Reconstruction Foundation
Eligibility Criteria
Inclusion Criteria
- •maxillary sinus atrophy in the need of sinus augmentation, 2 stage augmentation procedure
Exclusion Criteria
- •drug abuse, additional augmentation procedure, heavy smokers, bisphosphonate abuse
Outcomes
Primary Outcomes
New bone formation
Time Frame: 3 year
Bone trephine specimen retrieved at implant placement were histomorphometrically analyzed. With special interest % of new bone formation,% of residual graft and % of connective tissue were evaluated and compared between bovine and porcine mineral bone used for sinus grafting.