Radiographic and Histomorphometric Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft on Ridge Preservation Versus Bovine Graft Only for Subsequent Implant Placement in the Maxillary Posterior Region, a Randomized Clinical Trial.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Tooth Mobility
- Sponsor
- Cairo University
- Enrollment
- 22
- Primary Endpoint
- Quantity of bone (vertical bone height)
- Status
- Not Yet Recruiting
- Last Updated
- last year
Overview
Brief Summary
Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary posterior ridge preservation.
Detailed Description
All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on bovine graft will be utilized for the study group and bovine raft only for the control group. After 6 months, patients will be evaluated histomorphometrically via core biopsy at the time of implant placement and radiographically via assessment of ridge height on CBCT. Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height from base line (1week) to 6 months postoperatively.
Investigators
Bashaer Maruf Jamaan Bayashot
principal investigator
Cairo University
Eligibility Criteria
Inclusion Criteria
- •Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium.
- •Age group: above 21 years
- •Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.
Exclusion Criteria
- •General contraindications to implant surgery.
- •Subjected to irradiation in the head and neck area less than 1 year before implantation.
- •Poor oral hygiene and motivation.
- •Severe bruxism or clenching.
- •Systemic, immunologic, or debilitating diseases that could affect normal bone healing \& local pathosis.
- •Treated or under treatment of intravenous amino bisphosphonates.
- •Active infection or severe inflammation in the area intended for implant placement.
- •Patients participating in other studies if the present protocol could not be properly followed.
- •Heavy smokers
Outcomes
Primary Outcomes
Quantity of bone (vertical bone height)
Time Frame: Quantity of bone (vertical bone height) by CBCT after 6 months
By CBCT
Secondary Outcomes
- Quality of bone(Histological analysis (Core biopsy) Percentage of newly formed bone after 6 months)