Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation.

Not Applicable

Not yet recruiting

• Conditions: Tooth Mobility
• Interventions: Procedure: microfragmented adipose tissue loaded on bovine graft

• Registration Number: NCT06457867
• Lead Sponsor: Cairo University

Brief Summary

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary posterior ridge preservation.

Detailed Description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on bovine graft will be utilized for the study group and bovine raft only for the control group.

After 6 months, patients will be evaluated histomorphometrically via core biopsy at the time of implant placement and radiographically via assessment of ridge height on CBCT.

Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height from base line (1week) to 6 months postoperatively.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-10
• Study First Submitted QC: 2024-06-10
• Last Update Submitted: 2024-06-10
• Study First Posted: 2024-06-13
• Last Update Posted: 2024-06-13
• Study Start: 2024-07-01
• Primary Completion: 2025-02-01
• Study Completion: 2025-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium.

  • Age group: above 21 years
  • Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

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Exclusion Criteria

• General contraindications to implant surgery.

  • Subjected to irradiation in the head and neck area less than 1 year before implantation.
  • Poor oral hygiene and motivation.
  • Severe bruxism or clenching.
  • Systemic, immunologic, or debilitating diseases that could affect normal bone healing & local pathosis.
  • Treated or under treatment of intravenous amino bisphosphonates.
  • Active infection or severe inflammation in the area intended for implant placement.
  • Patients participating in other studies if the present protocol could not be properly followed.
  • Heavy smokers

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
bovine graft	microfragmented adipose tissue loaded on bovine graft	bovine graft only on ridge preservation
microfragmented adipose tissue	microfragmented adipose tissue loaded on bovine graft	microfragmented adipose tissue loaded on bovine graft on ridge preservation

Primary Outcome Measures

Name	Time	Method
Quantity of bone (vertical bone height)	Quantity of bone (vertical bone height) by CBCT after 6 months	By CBCT

Secondary Outcome Measures

Name	Time	Method
Quality of bone	Histological analysis (Core biopsy) Percentage of newly formed bone after 6 months	Histological analysis (Core biopsy) Percentage of newly formed bone