Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation

Not Applicable

Not yet recruiting

• Conditions: Hopeless Tooth
• Interventions: Procedure: microfragmented adipose tissue loaded on allograft

• Registration Number: NCT06636461
• Lead Sponsor: Cairo University

Brief Summary

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by radiographic and Histomorphometry ) utilizing microfragmented adipose tissue loaded on allograft versus allograft only for maxillary posterior ridge preservation

Detailed Description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on allograft will be utilized for the study group and allograft only for the control group.

After 3-6 months, assessment of dimensional changes ( RG height \& width) on CBCT is performed and Histomorphometry will be evaluated via core biopsy at the time of implant placement in both groups.

Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height and width from base line (1week) to 3-6 months postoperatively.

Study Timeline

• Study First Submitted: 2024-09-02
• Status Verified: 2024-10
• Study First Submitted QC: 2024-10-09
• Last Update Submitted: 2024-10-09
• Study First Posted: 2024-10-10
• Last Update Posted: 2024-10-10
• Study Start: 2024-11-01
• Primary Completion: 2025-01-01
• Study Completion: 2025-02-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium.

Age group: above 18 years

• Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

Exclusion Criteria

• • General contraindications to implant surgery.

  • Subjected to irradiation in the head and neck area less than 1 year before implantation.
  • Poor oral hygiene and motivation.
  • Severe bruxism or clenching.
  • Systemic, immunologic or debilitating diseases that could affect normal bone healing & local pathosis.
  • Treated or under treatment of intravenous amino-bisphosphonates.
  • Active infection or severe inflammation in the area intended for implant placement.
  • Patients participating in other studies, if the present protocol could not be properly followed.
  • Heavy somkers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
microfragmented adipose tissue	microfragmented adipose tissue loaded on allograft	microfragmented adipose tissue loaded on allograft on ridge preservation
allograft	microfragmented adipose tissue loaded on allograft	allograft only on ridge preservation

Primary Outcome Measures

Name	Time	Method
Alveolar ridge hight (bone quantity )	Alveolar ridge hight (bone quantity ) by CBCT after 3-6 months	By CBCT

Secondary Outcome Measures

Name	Time	Method
Alveolar ridge width.	Alveolar ridge width. by CBCT after 3-6 months	By CBCT

Trial Locations

Locations (1)

Cairo Universty; 🇪🇬 Cairo, Giza, Egypt