Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 228
- 试验地点
- 1
- 主要终点
- The number of participants who achieved a clinical pregnancy in a transfer cycle
研究概览
简要总结
In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.
详细描述
To date, a limited number of studies have been performed in order to assess whether the addition of GH can improve the probability of pregnancy in poor responders undergoing ovarian stimulation for IVF. Moreover, the existing studies are underpowered and, thus, inconclusive.
In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Serum anti-Müllerian hormone (AMH) less than 1.2 ng/ml
排除标准
- 未提供
研究组 & 干预措施
Growth hormone/HPuFSH/GnRH antagonist
The patients receive growth hormone
干预措施: Growth hormone/HPuFSH/GnRH antagonist (Drug)
HPuFSH/GnRH antagonist
Growth hormone is not used
干预措施: HPuFSH/GnRH antagonist (Drug)
结局指标
主要结局
The number of participants who achieved a clinical pregnancy in a transfer cycle
时间窗: Five weeks after embryo transfer
次要结局
- The number of participants who achieved a ongoing pregnancy in a transfer cycle(Eighteen weeks after embryo transfer)