To Evaluate the Effect of GnRH Agonist Administered in the Luteal Phase on ART Cycle Outcomes in Both GnRH Agonist and GnRH Antagonist Treated Ovarian Stimulation Protocols
Overview
- Phase
- Not Applicable
- Intervention
- vaginal progesterone
- Conditions
- Infertility
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Live Birth Rate
- Last Updated
- 12 years ago
Overview
Brief Summary
This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol.
Detailed Description
This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol. Decision between each of these two protocols was subjective and depended on the clinical context.In addition to routine luteal phase support with progesterone and estradiol valerate,women received two dose of GnRH agonist on the fifth and tenth day after ET.Live birth rate was the primary outcome measure.
Investigators
Nagihan CENGAVER
Resident
Zekai Tahir Burak Women's Health Research and Education Hospital
Eligibility Criteria
Inclusion Criteria
- •Couples undergoing ART with their own gametes.
- •Couples having at least one good embryo available for transfer.
- •Normoresponder
- •Infertility etiology is unexplained
- •ovulation triggered by intramuscular injection of 10000 IU of HCG
Exclusion Criteria
- •Patients older than 38 years old
- •High and poor responder patients
Arms & Interventions
LongGnRH agonist protocol(controlgroup)
Long GnRH agonist protocol ( control group) Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate
Intervention: vaginal progesterone
LongGnRH agonist protocol(controlgroup)
Long GnRH agonist protocol ( control group) Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate
Intervention: 4 mg oral estradiol valerate
antagonist protocol-leuprolide acetate
GnRH antagonist protocol Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate + subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: Leuprolide acetate
Long protocol-leuprolide acetate
Long GnRH agonist protocol Luteal Phase Support: Vaginal progesterone+oral estradiol valerate subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: Leuprolide acetate
Long protocol-leuprolide acetate
Long GnRH agonist protocol Luteal Phase Support: Vaginal progesterone+oral estradiol valerate subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: vaginal progesterone
Long protocol-leuprolide acetate
Long GnRH agonist protocol Luteal Phase Support: Vaginal progesterone+oral estradiol valerate subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: 4 mg oral estradiol valerate
GnRHantagonist protocol(control group)
GnRH antagonist protocol ( control group) Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate
Intervention: vaginal progesterone
GnRHantagonist protocol(control group)
GnRH antagonist protocol ( control group) Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate
Intervention: 4 mg oral estradiol valerate
antagonist protocol-leuprolide acetate
GnRH antagonist protocol Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate + subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: vaginal progesterone
antagonist protocol-leuprolide acetate
GnRH antagonist protocol Luteal Phase Support: Vaginal progesterone + 4mg oral estradiol valerate + subcutaneous 0.5mg leuprolide acetate fifth and tenth day after embryo transfer
Intervention: 4 mg oral estradiol valerate
Outcomes
Primary Outcomes
Live Birth Rate
Time Frame: 42 weeks
Secondary Outcomes
- Ongoing pregnancy(more than 20 weeks)
- miscarriage(up to 20 weeks)
- OHSS(up to 10 weeks)