临床试验/NCT04407052

NCT04407052Unknown2 期

Double Trigger in Patients With Low Proportion of Mature Oocytes. A Randomized Controlled Trial

Riyadh Fertility and Reproductive Health center1 个研究点分布在 1 个国家目标入组 66 人开始时间: 2020年5月30日最近更新: 2020年5月29日

适应症

干预措施

试验速览

阶段: 2 期
发起方
入组人数: 66
试验地点: 1
主要终点: Number of oocytes retrieved

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Single (Outcomes Assessor)

入排标准

年龄范围: 18 Years 至 35 Years（Adult）
性别: Female
接受健康志愿者: 否

入选标准

•Patients with history of low proportion of mature oocytes in previous IVF attempt (triggered by HCG).
•Patients with 6 to 15 mature follicles on the day oocyte trigger in the current IVF-ET attempt

排除标准

•Endometriosis

研究组 & 干预措施

Double trigger

Experimental

GnRH-agonist and HCG are used to trigger ovulation

干预措施: Double trigger (Drug)

HCG

Active Comparator

HCG is used to trigger ovulation

干预措施: HCG trigger (Drug)

结局指标

主要结局

Number of oocytes retrieved

时间窗: First day after oocyte retrieval

次要结局

Clinical pregnancy rate(First 5 weeks after oocyte retrieval)

研究者

发起方

Riyadh Fertility and Reproductive Health center

申办方类型

Other

责任方

Sponsor

研究点 (1)

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