Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients

Not Applicable

Completed

• Conditions: Diabetes; Healthy
• Interventions: Drug: intra-articular infiltration; Drug: epidural infiltration

• Registration Number: NCT01420497
• Lead Sponsor: Centre Hospitalier Universitaire Vaudois

Brief Summary

Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural, secondly to compare the amount of systemic diffusion of the drug the after both procedures.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-08
• Primary Completion: 2008-09
• Study Completion: 2010-06
• Status Verified: 2011-08
• Study First Submitted: 2011-08-18
• Study First Submitted QC: 2011-08-18
• Last Update Submitted: 2011-08-18
• Study First Posted: 2011-08-19
• Last Update Posted: 2011-08-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• diabetes stable for more than ten days
• no contraindication for steroids
• lumbar stenosis
• articular pain

Exclusion Criteria

• unstable diabetes
• renal insufficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
methylprednisolone,infiltration	intra-articular infiltration	-
epidural injection	epidural infiltration	-

Primary Outcome Measures

Name	Time	Method
glycemic values,	day 0 to day 15

Secondary Outcome Measures

Name	Time	Method
urinary excretion rate	day 0 to day 15

Trial Locations

Locations (1)

CHUV; 🇨🇭 Lausanne, VD, Switzerland