Physiological Effects of APRVplus and TCAV in ARDS

Not Applicable

Completed

• Conditions: ARDS (Acute Respiratory Distress Syndrome)

• Registration Number: NCT06748807
• Lead Sponsor: West China Hospital

Brief Summary

In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed. This study aims to compare the physiological effects of two types of APRV ventilation strategy, Early Pathophysiology-driven APRV (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV), through randomized crossover trials, providing evidence for clinical application and further research on APRV.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-15
• Status Verified: 2024-12
• Primary Completion: 2024-12-15
• Study Completion: 2024-12-15
• Study First Submitted: 2024-12-19
• Study First Submitted QC: 2024-12-19
• Last Update Submitted: 2024-12-19
• Study First Posted: 2024-12-27
• Last Update Posted: 2024-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• intubated and mechanically ventilated patients
• meet the 2023 global new definition of ARDS

Exclusion Criteria

• Pregnancy
• The expected duration of mechanical ventilation was less than 48 hours
• Intracranial hypertension (suspected or confirmed)
• Neuromuscular disorders that are known to prolong the need for mechanical ventilation
• Known or suspected chronic obstructive pulmonary disease(COPD)
• Terminal stage of disease
• Pneumothorax (drained or not)at enrollment
• Treatment with extracorporeal support (ECMO) at enrollment
• There was a lack of commitment to life support

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
△PL（PLThigh - PLTlow)	during the mechanical ventilation procedure	Transpulmonary pressure swings (△PL) equal to PLThigh - PLTlow

Secondary Outcome Measures

Name	Time	Method
EtCO2	during the mechanical ventilation procedure	end-tidal carbon dioxide
GI	during the mechanical ventilation procedure	global inhomogeneity
PaO2(mmHg)	during the mechanical ventilation procedure	the arterial partial pressure of oxygen

Trial Locations

Locations (1)

West China Hospital, Sichuan University; 🇨🇳 Chengdu, Sichuan, China