The role of surgical removal of the adrenal gland in improving heart and blood vessel disease in patients with adrenal gland nodule and increased secretion of the hormone cortisol

Not Applicable

Recruiting

• Conditions: Adrenal Gland Diseases; Adrenocortical hyperfunction; Metabolic syndrome; C19.053; C19.053.800; C18.452.394.968.500.570

• Registration Number: RBR-4ytbnk
• Lead Sponsor: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

All patients diagnosed with adrenal incidentaloma and characteristics suggestive of benignity in CT and/or MRI of the abdomen (homogeneous image, density <10UH pre-contrast, absolute washout>60%). Patients who meet these criteria will be invited to participate in the study, involving surgical treatment (laparoscopic adrenalectomy) of their adrenal incidentalomas and/or medication of their comorbidities. Patients with bilateral lesions will undergo adrenalectomy of the larger lesion

Exclusion Criteria

Patients with adrenal incidentaloma and diagnosis of pheochromocytoma, primary hyperaldosteronism, Cushing's syndrome overt, adrenal carcinoma or malignancies including extra adrenal metastases; high adrenocorticotropic hormone concentration; history of alcoholism; administration of drugs that may influence cortisol metabolism, dexamethasone or cortisol secretion; patients undergoing previous open abdominal surgery; chronic renal insufficiency or any contraindication for surgery.

Study & Design

• Study Type: Intervention
• Study Design: Not specified