Cardio-metabolic consequences of mild adrenal glucocorticoid excess

Not Applicable

Completed

• Conditions: adrenal adenoma; cardio-metabolic disease; Metabolic and Endocrine - Other endocrine disorders; Metabolic and Endocrine - Metabolic disorders; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12620000654954
• Lead Sponsor: Morton Burt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-05
• Study Completion: 2022-08-21
• Last Update Posted: 27 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

Adrenal adenoma incidentally identified on computer tomography scan of the abdomen to investigate some other unrelated complaint
- Morning cortisol between 50 - 140 nmol/L after 1mg dexamthasone suppression test (Group 1)
- Morning cortisol < 50 nmol/L after 1mg dexamethasone suppression test (Group 2)

Exclusion Criteria

1.Prescribed oral prednisolone, hydrocortisone or dexamethasone in the last 6 months
2.Regular inhaled glucocorticoid therapy
3.Regular oral oestrogen, phenytoin or carbamazepine therapy
4.Pregnancy
5.Uncontrolled depression or depressive illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified