Functional Magnetic Resonance Imaging and Reading Deficit in Children With NF1 Children
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Percentage of children performing in full the protocol functional MRI
Study Overview
Brief Summary
A monocenter pilot study on the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.
Detailed Description
The principal aim of the study is to highlight the activation of brain area involved phonological and visuo-spatial processing in children with NF1 with or without reading disabilities.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 8 Years to 12 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age included between 8 and 12 years
- •Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list :
- •At least 6 café au lait spots
- •2 or more neurofibromas or 1 plexiform neurofibroma
- •axillary or inguinal freckling
- •1 optic nerf glioma
- •2 or more Lisch nodules
- •1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudarthrosis
- •1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria
- •Membership in a national insurance
- •Consent of the child and the parents
Exclusion Criteria
- •Mental retardation (QI T < 70)
- •Treated or untreated epilepsy
- •Visual deficit (visual Acuteness < 4/10
- •Presence of a symptomatic optic glioma
- •Presence of a brain tumor.
Arms & Interventions
Children with reading disability
Children with NF1, with reading disability if their performances on reading assessment (Alouette Test) present a delay of at least 18 months, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis
Intervention: Neuropsychological assessments (Other)
Children with reading disability
Children with NF1, with reading disability if their performances on reading assessment (Alouette Test) present a delay of at least 18 months, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis
Intervention: morphological and functional MRI (fMRI) (Radiation)
Children with reading disability
Children with NF1, with reading disability if their performances on reading assessment (Alouette Test) present a delay of at least 18 months, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis
Intervention: genetic analysis (Genetic)
Children without reading disability
Children with NF1, without reading disability if their performances on reading assessment (Alouette Test) present a less than 18-month delay, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis.
Intervention: Neuropsychological assessments (Other)
Children without reading disability
Children with NF1, without reading disability if their performances on reading assessment (Alouette Test) present a less than 18-month delay, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis.
Intervention: morphological and functional MRI (fMRI) (Radiation)
Children without reading disability
Children with NF1, without reading disability if their performances on reading assessment (Alouette Test) present a less than 18-month delay, will have Neuropsychological assessments, morphological and functional MRI (fMRI) and genetic analysis.
Intervention: genetic analysis (Genetic)
Outcomes
Primary Outcomes
Percentage of children performing in full the protocol functional MRI
Time Frame: day 1
Study the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.
Secondary Outcomes
- blood flow in milliliters per minute(day 1)