Towards Realtime High-resolution Treatment Monitoring in Humans: Using Ultrasound Imaging to Monitor Low-intensity Focused Ultrasound Neuromodulation
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Detecting task-evoked changes
研究概览
简要总结
This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).
详细描述
A battery of tasks will be performed under two imaging conditions. Magnetic Resonance Imaging and transcranial functional ultrasound imaging. Tasks include a breath hold task, an e-stim task, and low-intensity focused ultrasound neuromod.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •See above.
排除标准
- •Claustrophobia
- •Contraindications to MRI (neurostims, metal implants, pacemakers, etc)
- •Contraindications to CT (pregnancy)
- •Active medical disorders with CNS effects (e.g. Alzheimers)
- •History of neurological disorder
- •History of head injury with LOC > 10 min
- •History of alcohol or drug dependence
研究组 & 干预措施
Arm 1 - all participants
All participants will receive two imaging modalities with corresponding tasks to compare imaging modalities.
干预措施: Feasibility of imaging using tFUS (Device)
结局指标
主要结局
Detecting task-evoked changes
时间窗: The duration of each task - ~10 minutes.
Detecting task-evoked changes using tFUS imaging
次要结局
- Detecting LIFU induced neural activity(During LIFU application, ~2 min.)
研究者
Wynn Legon
Assistant Professor
Virginia Polytechnic Institute and State University