Predictive Nomogram for Postoperative Acute Kidney Injury in Older Patients Undergoing Noncardiac Surgery

• Conditions: Postoperative Acute Kidney Injury
• Interventions: Other: no intervention

• Registration Number: NCT05507268
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Postoperative acute kidney injury is associated increased risk of morbidity and mortality. Older patients are at high risk of developing postoperative acute kidney injury. However, the incidence and associations of postoperative acute kidney injury in older patients are not well understood. This study aims to develop and validate a predictive nomogram for postoperative acute kidney injury in older patients undergoing noncardiac surgery.

Detailed Description

Postoperative acute kidney injury (AKI) affects approximately 2% to 40% of patients undergoing cardiac and major noncardiac surgeries.

Older patients are more susceptible to renal impairment than younger patients. However, the incidence and associations of AKI in older patients are rarely understood.

Generally, in-depth knowledge of risk factors and thus able to identify patients at high risk to develop postoperative AKI is essential to optimize perioperative prevention and protection strategies.

In this retrospective study, the investigators intend to develop and validate a predictive model for postoperative using the identified risk factors.

The primary outcome is postoperative AKI, which according to the Kidney Disease: Improving Global Outcomes (KDIGO) criterion, is defined as an absolute increase in serum creatinine of 0.3 mg/dL within 48 hours or a 1.5-fold increase from preoperative baseline within 7 days after surgery.

Study Timeline

• Study Start: 2022-04-01
• Status Verified: 2022-08
• Study First Submitted: 2022-08-17
• Study First Submitted QC: 2022-08-17
• Last Update Submitted: 2022-08-17
• Study First Posted: 2022-08-18
• Last Update Posted: 2022-08-18
• Primary Completion: 2022-12-30
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50000

Inclusion Criteria

• Patients aged 65 years and older

Exclusion Criteria

• Emergency operation
• Cardiac surgery
• Incomplete data
• Incomplete data
• Local anesthesia
• Preoperative renal failure or requirement for dialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
older patients undergoing noncardiac surgery	no intervention	older patients (aged ≥65 years) scheduled for noncardiac surgery

Primary Outcome Measures

Name	Time	Method
acute kidney injury	7 days after surgery	an absolute increase in serum creatinine of 0.3 mg/dl within 48 hours or a 1.5-fold increase from preoperative baseline within 7 days after surgery

Trial Locations

Locations (1)

the First Medical Center of Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China