Upper Extremity Function, Shoulder Position Sense and Disability Level İn Patients With Multiple Sclerosis

Not Applicable

Completed

• Conditions: Position Sense; Physical Therapy; Upper Extremity Function
• Interventions: Other: Upper extremity function; Other: Shoulder position sense

• Registration Number: NCT03846336
• Lead Sponsor: Ankara Yildirim Beyazıt University

Brief Summary

The purposes of this study is to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis (MS) and which best projects the disability status.

Upper extremity dysfunction is considered to be the main cause of the loss performance of activities of daily living and this problem was include all motor and somatosensory components of function. Any failure in each of these components will likely create an impairment in the normal function.

One of the most important components of the somatosensory system is joint position sense, a sub-modality of proprioception. Position sense disorders are seen from the early stages of the disease and upper extremity function problems is experienced depending on position sense disorders in patients with MS.

Expanded Disability Status Scale (EDSS) is one of the most commonly outcome measures in evaluating the level of disability in MS population. Because EDSS scale emphasis on ambulation, so it is insensitive to upper extremity function. But the ability to use walking aids (e.g., canes, walkers, wheelchairs, etc.) may be affected by the UE impairment so shoulder position sense.

When literature is examined, there is no study which examines the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis and which best projects the disability status. For all these reasons, we think that shoulder position sense is changed both dominant and non-dominant side during flexion and abduction movements in mild-moderate MS patients and that these deficits are correlated with upper extremity function and disability level.

Detailed Description

This study was aimed to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with MS and which best projects the disability status.

21 PwMS and 20 healthy volunteers with matching ages and genders were included the study. A neurologic examination was performed using the EDSS by a neurologist.

Upper extremity function was evaluated with 9-Hole Peg Test (9-HPT). Shoulder position sense was evaluated with Dualer IQTM digital inclinometer (J-TECH medical, Salt Lake City, UK, USA).

Study Timeline

• Study Start: 2018-06-01
• Primary Completion: 2018-07-01
• Study Completion: 2018-09-01
• Status Verified: 2019-02
• Study First Submitted: 2019-02-17
• Study First Submitted QC: 2019-02-17
• Last Update Submitted: 2019-02-17
• Study First Posted: 2019-02-19
• Last Update Posted: 2019-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Clinical diagnosis of Multiple Sclerosis Disease
• The level of disability should be between 0.5-4 according to EDSS

Exclusion Criteria

• Patients with acute attacks (three months prior to the study)
• Mini-Mental State Examination (MMSE) score of less tahn 25 points
• History of shoulder injury, surgery, medical problems or other neurological disorders in any of the participants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Multiple Sclerosis	Upper extremity function	Patients with confirmed diagnosis of clinically definite MS and physician-administered EDSS range of 1-3.5.
Multiple Sclerosis	Shoulder position sense	Patients with confirmed diagnosis of clinically definite MS and physician-administered EDSS range of 1-3.5.
Healthy individuals	Upper extremity function	20 healthy volunteers with matching ages and genders.
Healthy individuals	Shoulder position sense	20 healthy volunteers with matching ages and genders.

Primary Outcome Measures

Name	Time	Method
Upper extremity function	1 month	Upper extremity function was evaluated with the 9-Hole Peg Test (9-HPT). It consists of moving nine pegs into one of the nine holes on a peg board, then back into an open box. A stopwatch was used for the measurements and the scores were recorded in seconds (s).

Secondary Outcome Measures

Name	Time	Method
Shoulder position sense	1 month	Shoulder position sense was evaluated with a Dualer IQTM digital inclinometer (J-TECH medical, Salt Lake City, UT, USA).The absolute error scores (in degrees) for shoulder abduction and flexion at 30° and 60° was calculated. The difference between the target angle and the observed angle was calculated and the absolute error score was recorded by taking the average of 3 trials.

Trial Locations

Locations (1)

Ankara Yıldırım Beyazıt University, Faculty of Health Sciences,Department of Physiotherapy and Rehabilitation; 🇹🇷 Ankara, Esenboğa, Turkey