Efficacy of pantoprazole suspension for prevention of peptic ulcer.
Phase 3
- Conditions
- peptic ulcer prevention.Peptic ulcer, site unspecified
- Registration Number
- IRCT2015070220178N5
- Lead Sponsor
- Iran University of Medical Sciences,Rasoul Akram Hospital,Colorectal Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
Patients older than 18 years who are admitted to medical and surgical ICUs with support of mechanical ventilation at least for 48 hours and nasogastric tube .
Exclusion criteria:active gastrointestinal bleeding,allergic history to pantoprazole ,co-administeration of prokinetic and other acid reducing drugs,past history of gastric surgery,nasogastric tube intolerance,liver failure,pregnancy, lactation,unexpected intragastric pH<0.8 and/or >10.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peptic ulcer prevention. Timepoint: basic ,first day,third day. Method of measurement: 24 hours intragastric PH monitoring.
- Secondary Outcome Measures
Name Time Method Gastrointestinal bleeding rate after treatment intervention. Timepoint: 1,3 ,7,14 and 28 days after treatment intervention. Method of measurement: Data gathering sheet and nasogastric tube exam.;Drug adverse effect such as pneumonia rate. Timepoint: 3 ,7, 14 and 28 days after treatment intervention. Method of measurement: Sign and symptom gathering sheet and chest x-ray.;Frequency ofunderlying etiologic factore for mechanical ventilation support. Timepoint: at the begining of treatment. Method of measurement: Data gathering sheet.