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Clinical Trials/NCT06392412
NCT06392412
Not yet recruiting
Not Applicable

Effects of Fully Immersive Virtual Reality Cognitive Training Based on Instrumental Activities of Daily Living for Older Adults With Mild Cognitive Impairment

Da-Yeh University0 sites52 target enrollmentOctober 1, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Mild Cognitive Impairment
Sponsor
Da-Yeh University
Enrollment
52
Primary Endpoint
Change scores of Lawton Instrumental Activities of Daily Living
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

This study aims to (1) develop and assess the feasibility of a fi-VRCT program based on IADL for older adults with MCI, (2) implement and evaluate the effectiveness of the fi-VRCT program based on IADL in older adults with MCI, and (3) investigate the potential mechanism of the fi-VRCT program based on IADL for older adults with MCI and refine this intervention accordingly.

Detailed Description

As research on cognitive training methods for older adults with mild cognitive impairment (MCI) progresses, fully immersive virtual reality cognitive training (fi-VRCT) has emerged as a promising approach. While the benefits of fi-VRCT for enhancing cognitive function have been recognized, its potential to improve instrumental activities of daily living (IADL) and promote independence remains uncertain. This study addresses these questions by developing and validating a fi-VRCT program based on IADL to enhance cognitive and IADL performance among older adults with MCI.

Registry
clinicaltrials.gov
Start Date
October 1, 2024
End Date
December 31, 2026
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Da-Yeh University
Responsible Party
Principal Investigator
Principal Investigator

I-Chen Chen

Assistant Professor

Da-Yeh University

Eligibility Criteria

Inclusion Criteria

  • Aged 65 or above.
  • MoCA score between 18 and
  • Capability to follow directions and do tasks.

Exclusion Criteria

  • History of dementia.
  • Previous neurodegenerative illness diagnosis.
  • Severe medical or surgical problems.
  • Major psychological disorders.
  • Inability to use VR system

Outcomes

Primary Outcomes

Change scores of Lawton Instrumental Activities of Daily Living

Time Frame: At baseline, at week 9, and at 3-month follow-up.

The Lawton Instrumental Activities of Daily Living is commonly employed to assess participants' ability to perform daily tasks and identify early functional decline. In semi-structured interviews, participants describe how they currently perform the eight IADLs. Each item is rated based on the levels of competence, ranging from independence in performing the activity to not being able to perform it at all. Score ranges from 8 to 31 and higher scores indicate better functional ability.

Changes scores of Montreal Cognitive Assessment (MoCA)

Time Frame: At baseline, at week 9, and at 3-month follow-up.

The MoCA comprises12 items, it assesses orientation to time and place, attention, concentration, short-term memory, \\working memory, visuospatial abilities, language, and executive function. Scores on the MoCA range from 0 to 30, with a higher score indicative of better global cognition. A total score of 26 or above is considered within the normal cognitive function range, while a total score of 18 to 25 indicates mild cognitive impairment

Change scores of Wechsler Memory Scale (WMS)

Time Frame: At baseline, at week 9, and at 3-month follow-up.

The Wechsler Memory Scale is a neuropsychological test designed to assess memory in adults aged 16 to 90. Family Pictures, Spatial Span, and Word List will be used to evaluate visual, auditory, immediate, delayed, and working memory. For each subtest, higher scores indicate better performance in memory performance. Based on age ranges, raw scores will be transformed into scaled scores ranging from 1 to 19.

Change scores of Amsterdam Instrumental Activities of Daily Living Questionnaire, Short Version

Time Frame: At baseline, at week 9, and at 3-month follow-up.

The questionnaire is informant-reported and is typically completed by a caregiver. It comprises 30 items in seven categories: household activities, household appliances, finances, work, computer use, appliances, and leisure activities. Each item is rated based on the difficulty levels in performing it, ranging from no difficulty in performing the task to no longer being able to perform it. Score ranges from 0 to 100 and lower score indicates better functional ability.

Secondary Outcomes

  • Change scores of Stroop Color-Word Test(At baseline, at week 9, and at 3-month follow-up.)
  • Change scores of Digit Span(At baseline, at week 9, and at 3-month follow-up.)

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