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Clinical Trials/NCT04342260
NCT04342260
Completed
Not Applicable

Improving Quality of Life After Thoracic Surgery Using Patient-Reported Outcomes

UNC Lineberger Comprehensive Cancer Center1 site in 1 country113 target enrollmentApril 30, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Thoracic Surgery
Sponsor
UNC Lineberger Comprehensive Cancer Center
Enrollment
113
Locations
1
Primary Endpoint
Quality of Life at 12 Months
Status
Completed
Last Updated
last year

Overview

Brief Summary

This study is designed to test if patient-reported outcomes with automated reporting to clinicians for remote monitoring of postoperative symptoms is feasible and improves quality of life, health outcomes, and service utilization in thoracic surgery patients. Patients undergoing thoracic surgery will be asked to self-report symptoms for remote monitoring by their care team.

Detailed Description

This is a single center, randomized feasibility study. A total of 140 patients undergoing thoracic surgery will be prospectively enrolled and randomized in a 1:1 ratio to one of two arms. All participants will complete patient-reported outcome (PRO) symptom monitoring. The two arms are 1) active symptom monitoring and 2) passive symptom monitoring. The participants randomized to active symptom monitoring will have alerts sent to their clinicians when their PRO symptom scores exceed baseline postoperative scores (when discharge day scores are available) by 2 points or more, or when 'severe' or 'very severe' symptoms are reported. Participants randomized to the passive PRO monitoring arm will complete the same PROs as participants in the active monitoring arm, but will not have alerts sent to their clinician. All participants will be administered survey instruments to assess quality of life, satisfaction, and health history. In addition, a subset of up to 40 participants will be chosen at 2 months postoperatively to complete a semi-structured interview about their postoperative symptom reporting experience.

Registry
clinicaltrials.gov
Start Date
April 30, 2020
End Date
November 10, 2023
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • 18 years or older
  • English speaking
  • Able and willing to complete web-based symptom survey
  • Be presenting for inpatient thoracic surgery

Exclusion Criteria

  • Not completing planned surgery within 3 months of obtaining informed consent
  • Diagnosis of esophageal cancer
  • Inability to read and speak English
  • Presenting for a day surgery
  • Presenting for foregut surgery (e.g. paraesophageal hernia repair)
  • Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent.
  • Current incarceration
  • Pregnancy

Outcomes

Primary Outcomes

Quality of Life at 12 Months

Time Frame: 12 months post-discharge

Quality of Life (QOL) will be measured by the EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) version 3.0 and reported as a score on a scale from 0 to 100 with a higher score being a better QOL.

Lung Cancer Specific Quality of Life at 12 Months

Time Frame: 12 months post-discharge

Lung cancer specific Quality of Life will be measured by the EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Lung Cancer-13 (EORTC QLQ-LC13) supplement and reported as a score from 0 to 100 with a higher score being worse symptoms

PRO Symptom Monitoring Surveys Completed at 3 Months

Time Frame: 3 months post-discharge

The percentage of subjects who completed symptom surveys out of delivered symptom surveys.

PRO Symptom Monitoring Alerts Resulting in a Clinician Response at 3 Months

Time Frame: 3 months post-discharge

The percentage of survey alerts that generate a clinician response will be calculated.

Barriers and Facilitators of PRO Monitoring After Thoracic Surgery

Time Frame: assessed at 2 months through 2 years post-discharge

Barriers and facilitators of PRO monitoring after thoracic surgery will be assessed using qualitative methods. A subset of patients and caregivers participated in semi-structured interviews. Thematic analysis was used to identify determinants.

Secondary Outcomes

  • Readmission at 3 Months(3 months post-discharge)
  • Overall Survival at 12 Months(12 months post-discharge)

Study Sites (1)

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