Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease

• Conditions: Diabetic Nephropathy

• Registration Number: NCT01458158
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.

Detailed Description

The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.

Study Timeline

• Study First Submitted: 2011-09-30
• Study Start: 2011-10
• Study First Submitted QC: 2011-10-21
• Study First Posted: 2011-10-24
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-20
• Last Update Posted: 2015-02-23
• Primary Completion: 2016-05
• Study Completion: 2016-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Chronic kidney disease
• Diabetes mellitus type 2

Exclusion Criteria

• Malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease	two years	Matrix metalloproteinases associated with atherosclerosis in chronic kidney disease;patients with diabetes mellitus type 2 and others with chronic glomerulonephritis.Serum levels of MMPs-2 and -9 are measured by an ELISA system.Intima Media Thickness(IMT) of carotid and femoral arteries is measured with a high resolution ultrasonography.

Secondary Outcome Measures

Name	Time	Method
Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease	two years	Matrix metalloproteinases associated with atherosclerosis markers,pro-inflammatory markers and markers of oxidative stress in chronic kidney disease

Trial Locations

Locations (1)

AHEPA University Hospital, Medical School of Aristotle University of Thessaloniki; 🇬🇷 Thessaloniki, Greece