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临床试验/NCT07668947
NCT07668947已完成不适用

Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy in the Management of Stage II Periodontitis (A Randomized Controlled Clinical Study With Biochemical Assessment )

Ain Shams University1 个研究点 分布在 1 个国家目标入组 117 人开始时间: 2025年10月13日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
117
试验地点
1

研究概览

简要总结

the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on periodontal health and how do IL-1B and IL-20 serve as mediators in the inflammatory processes linked to periodontal disease?

详细描述

the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on periodontal health and how do IL-1B and IL-20 serve as mediators in the inflammatory processes linked to periodontal disease? .A randomized controlled clinical trial will be conducted on patients with periodontitis stage II . participants will be allocated to one of three groups: traditional smokers , vapers and non-smokers . the randomization process will ensure unbiased distribution of participants across the groups . periodontal health will be evaluated through clinical assesment ( probing depth as primary outcome, clinical attachemt level, bleeding on probing and GI ) then cytokine levels (IL-1B , IL-20) will be assessed.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • pts aged 20-40 years
  • pts with stage II periodontitis
  • systemically healthy with no chronic diseases
  • no current use of medication
  • participants have the same socioeconomic status
  • participants must be able to understand and comply with the study protocol and give informed consent

排除标准

  • pts with severe systemic diseases
  • recent use of immunosuppressants or medications that affect oral health
  • history of illicit drug use within the past 12 months
  • periodontal surgery or scaling within the last 6 months
  • participants in another clinical trial
  • vulnerable individuals as children and pregnant

研究组 & 干预措施

non smokers

Active Comparator

pts with stage II periodontitis who are non smokers and recieved non surgical periodontal therapy

干预措施: non surgical periodontal therapy (Procedure)

traditional smokers

Active Comparator

patients with stage II periodotitis who are conventional cigarette smokers and recieved non surgical periodontal therapy

干预措施: non surgical periodontal therapy (Procedure)

e-cigarette smokers

Active Comparator

pts with stage II periodontitis who are on e-cigarette smoking and recieved non surgical periodontal therapy

干预措施: non surgical periodontal therapy (Procedure)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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