Right Ventricular Haemodynamic Evaluation and Response to Treatment
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Right Ventricular Dysfunction
- Sponsor
- University of Giessen
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Comparibility of Ees (endsystolic elastance, which describes the right ventricular contractility) derived from conductance catheter, cMRI (cardiac magnetic resonance tomography) and 4D echocardiography
- Last Updated
- 5 years ago
Overview
Brief Summary
Mono-center Study to evaluate different multimodal functional parameter of the right ventricle in PAH-patients
Detailed Description
Mono-center-study tu evaluate functional parameters in cardiac MRI, conductance catheter (pressure-volume-loops), echocardiography and right heart catheter in PAH patients and to compare different multimodal parameters
Investigators
Jan Grimminger
Principle Investigator
University of Giessen
Eligibility Criteria
Inclusion Criteria
- •PH Nizza group 1 and patients without pulmonary hypertension after having the right heart catheter on clinical grounds
- •ability to sign informed consent
- •male and female between 18 to 85 years
- •haemodynamic criteria:
- •Pulmonary vascular resistance (PVR) \> 240 dyn x sec x cm-5
- •Mean Pulmonary artery pressure (mPAP) ≥ 25 mmHg for PAH patients
- •normal haemodynamic in controls
- •therapy-naive or at least since two months stabil therapy with approved drugs for PAH (Sildenafil, Tadalafil, Macitentan, Ambrisentan, Bosentan, Iloprost, Treprostinil, Riociguat).
Exclusion Criteria
- •therapy with positive inotropic drugs (dobutamin etc.)
- •missing informed consent
- •pregnancy or lactation
Outcomes
Primary Outcomes
Comparibility of Ees (endsystolic elastance, which describes the right ventricular contractility) derived from conductance catheter, cMRI (cardiac magnetic resonance tomography) and 4D echocardiography
Time Frame: 12 weeks
right ventricular contractility can be obtained via different methods, our aim is to compare the different methods. Ees is the endsystolic elastance which describes the contractility of the right ventricle
Secondary Outcomes
- dp/dt max and min from Pressure-Wire vs. Conductance Katheter(12 weeks)
- Comparibility of volumetry assessed via magnetic resonance tomography (MRI) and 4D echocardiography (ECHO)(12 weeks)
- Comparibility of pressures measured via pressure wire and conductance catheter(12 weeks)