Writing About Experiences and Health in Older Adults II
概览
- 阶段
- 1 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Social Psychology
- 发起方
- University of California, Los Angeles
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Change in Dorsal Anterior Cingulate Cortex (dACC) Activity in response to stress
- 状态
- 招募中
- 最后更新
- 上个月
概览
简要总结
UCLA researchers looking for healthy older adults (aged 65+) to participate in a study investigating how writing about experiences can affect your brain and body.
Once a week for 6 weeks, participants will write about their experiences and fill out online questionnaires. Participants will also come to the UCLA campus to complete a neuroimaging session (fMRI), provide a blood spot sample, and fill out questionnaires 2 times: once prior to the 6-week writing period and once immediately after the 6-week writing period.
研究者
Naomi Eisenberger
Professor of Psychology
University of California, Los Angeles
入排标准
入选标准
- •Healthy adults age 65 years and older
排除标准
- •current smokers
- •active, uncontrolled medical disorders
- •chronic infection (e.g., Hepatitis C, HIV)
- •use of certain medications (steroid use, opioid use)
- •psychiatric disorders (e.g., current major depression, bipolar disorder)
- •body mass index (BMI) greater than 35
- •left-handed
- •claustrophobic
- •metal in body
- •Other exclusion criteria may apply.
结局指标
主要结局
Change in Dorsal Anterior Cingulate Cortex (dACC) Activity in response to stress
时间窗: Baseline, 6 weeks
Parameter estimates from dACC region-of-interest
Change in Septal Area Activity in response to prosocial behavior
时间窗: Baseline, 6 weeks
Parameter estimates from septal area region-of-interest
Change in Psychological Distress
时间窗: Baseline, 6 weeks, 10 weeks
Composite measure of depression, anxiety, stress (Beck Depression Inventory, Spielberger Trait Anxiety, and Perceived Stress Scale)
Change in Social Support
时间窗: Baseline, 6 weeks, 10 weeks
measure of perceived social support (Social Provisions Scale)
Change in Social Participation
时间窗: Baseline, 6 weeks, 10 weeks
measure of participation in social activities (Lifestyle Activities Questionnaire)
Change in Anterior Insula Activity in response to stress
时间窗: Baseline, 6 weeks
Parameter estimates from bilateral anterior insula region-of-interest
Change in Ventral Striatum Activity in response to prosocial behavior
时间窗: Baseline, 6 weeks
Parameter estimates from bilateral ventral striatum region-of-interest
Change in Inflammatory Gene Expression
时间窗: Baseline, 6 weeks, 10 weeks
changes in proinflammatory gene expression
Change in Amygdala Activity in response to threat
时间窗: Baseline, 6 weeks
Parameter estimates from bilateral amygdala region-of-interest
次要结局
- Change in Memory(Baseline, 6 weeks, 10 weeks)
- Change in Beliefs about Aging(Baseline, 6 weeks, 10 weeks)