NSAIDs Treatment in Children With Pleuropneumonia
- Registration Number
- NCT01586299
- Lead Sponsor
- Rabin Medical Center
- Brief Summary
The purpose of this study is to evaluate the influence of routine NSAIDs treatment for hospitalized children with pleuropneumonia in comparison with acetominophen treatment (all in conjunction with adequate antibiotic therapy).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- age less than 18 years
- admission in Schneider childrenMC of Israel, wards a/c
- clinical diagnosis of pneumonia with evidence of pleural effusion on chest X-ray
- parental informed consent
- follow-up ability after discharge
Exclusion Criteria
- pneumonia secondary to foreign body aspiration
- immune deficiency
- chronic lung disease other than asthma (CF, CLD of prematurity, Familial Dysautonomia, etc)
- significant premorbidity (organ failure, rheumatic disease, etc)
- endotracheal/endobronchial devices including tracheostomy.
- parental refusal to participate in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description acetaminophen Acetaminophen - ibuprofen Ibuprofen -
- Primary Outcome Measures
Name Time Method clinical improvement as manifested by resolution of fever and length of hospital admission. participants will be followed for the duration of hospital stay, an expected average of 10 days
- Secondary Outcome Measures
Name Time Method clinical improvement as manifested by respiratory parameters (tachypnea, dyspnea, Fio2),and inflammatory markers. participants will be followed for the duration of hospital stay, an expected average of 10 days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does COX-2 inhibition by ibuprofen modulate inflammation in pediatric pleuropneumonia compared to acetaminophen's mechanism?
What is the comparative efficacy of ibuprofen versus acetaminophen in reducing fever and pain in children with pleuropneumonia receiving antibiotics?
Which inflammatory biomarkers predict response to ibuprofen or acetaminophen in hospitalized children with pleuropneumonia?
What are the safety profiles and adverse event management strategies for ibuprofen and acetaminophen in pediatric pleuropneumonia trials?
How do combination therapies of NSAIDs and corticosteroids compare to monotherapy in treating pleuropneumonia in children?
Trial Locations
- Locations (1)
Schneider's medical center of Israel
🇮🇱Petah Tikva, Israel