Clinical Study on Endometrial Receptivity

Early Phase 1

• Conditions: Endometrial Receptivity;RNA; Progesterone
• Interventions: Drug: Progesterone

• Registration Number: NCT03687021
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-08
• Study First Submitted: 2018-08-13
• Study First Submitted QC: 2018-09-25
• Last Update Submitted: 2018-09-25
• Study First Posted: 2018-09-27
• Last Update Posted: 2018-09-27
• Study Start: 2018-10-10
• Primary Completion: 2018-10-10
• Study Completion: 2018-11-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 35

Inclusion Criteria

1. The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal.

   control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal

2. progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40

Exclusion Criteria

Patients with medical complications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
vaginal progesterone	Progesterone	vaginal progestin (90mg)
oral progesterone	Progesterone	oral progestin(40mg)
Intramuscular progesterone	Progesterone	Intramuscular progestin(20mg)

Primary Outcome Measures

Name	Time	Method
endometrial receptivity measured by pathology	3 months	35 samples will be measured.

Secondary Outcome Measures

Name	Time	Method
endometrial receptivity measured by immunohisochemistry	3 months	35 samples will be measured
endometrial receptivity measured by Ribose Nucleic Acid （RNA）	3 months	35 samples will be measured
endometrial receptivity measured by scanning electron microscope	3 months	35 samples will be measured

Trial Locations

Locations (1)

Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences; 🇨🇳 Beijing, Beijing, China