Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury

Phase 2

• Conditions: Acute Lung Injury; Acute Respiratory Distress Syndrome; Respiratory Failure
• Interventions: Procedure: PEEP titration

• Registration Number: NCT01326208
• Lead Sponsor: University Hospital, Bonn

Brief Summary

The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-07-15
• Status Verified: 2011-03
• Study Start: 2011-03
• Study First Submitted QC: 2011-03-29
• Last Update Submitted: 2011-03-29
• Study First Posted: 2011-03-30
• Last Update Posted: 2011-03-30
• Primary Completion: 2012-12
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• acute lung injury, need for optimization of ventilatory settings

Exclusion Criteria

• preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Acute Lung Injury / ARDS	PEEP titration	Patient under mechanical suffering from ALI or ARDS

Primary Outcome Measures

Name	Time	Method
homogeneity of regional ventilation delay	up to eight hours	influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography

Secondary Outcome Measures

Name	Time	Method
pulmonary gas exchange, lung mechanics and ventilation/perfusion matching	up to eight hours	influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching

Trial Locations

Locations (1)

University Hospital; 🇩🇪 Bonn, Germany