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Interaction of Potassium and Genetic Risk Variants on Diabetes Risk

Completed
Conditions
Diabetes
Registration Number
NCT03367455
Lead Sponsor
Duke University
Brief Summary

The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
11812
Inclusion Criteria
  • Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts
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Exclusion Criteria
  • Had not fasted 8 or more hours for the baseline visit
  • Prevalent diabetes at baseline exam
  • Missing information on serum potassium
  • Missing single nucleotide polymorphism (SNP) data
  • Evidence of kidney dysfunction
  • Race other than black/African American or white/Caucasian
  • Missing other covariates
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratiothrough study completion, mean of 8 years of follow-up

Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort

Secondary Outcome Measures
NameTimeMethod
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