Interaction of Potassium and Genetic Risk Variants on Diabetes Risk
- Conditions
- Diabetes
- Registration Number
- NCT03367455
- Lead Sponsor
- Duke University
- Brief Summary
The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11812
- Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts
- Had not fasted 8 or more hours for the baseline visit
- Prevalent diabetes at baseline exam
- Missing information on serum potassium
- Missing single nucleotide polymorphism (SNP) data
- Evidence of kidney dysfunction
- Race other than black/African American or white/Caucasian
- Missing other covariates
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio through study completion, mean of 8 years of follow-up Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort
- Secondary Outcome Measures
Name Time Method