Blockade of Vascular Potassium Channels During Human Endotoxemia

Phase 1

Completed

• Conditions: Endotoxemia

• Registration Number: NCT00185003
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01
• Primary Completion: 2005-06
• Study Completion: 2005-06
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-16
• Status Verified: 2008-04
• Last Update Submitted: 2008-10-16
• Last Update Posted: 2008-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• healthy volunteers

Exclusion Criteria

• drug, alcohol, nicotine abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Hemodynamics	24 hrs after LPS administration
Markers of Inflammation	24 hrs after LPS administration
Cytokines	24 hrs after LPS administration
Markers of Renal Injury	24 hrs after LPS administration
Inducible NO synthase expression	24 hrs after LPS administration
NO-metabolites	24 hrs after LPS administration
Mediators of Vascular reactivity	24 hrs after LPS administration
Sensitivity to norepinephrine	24 hrs after LPS administration