Blockade of Vascular Potassium Channels During Human Endotoxemia
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 36
- 主要终点
- Hemodynamics
研究概览
简要总结
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
排除标准
- •drug, alcohol, nicotine abuse
结局指标
主要结局
Hemodynamics
时间窗: 24 hrs after LPS administration
Markers of Inflammation
时间窗: 24 hrs after LPS administration
Cytokines
时间窗: 24 hrs after LPS administration
Markers of Renal Injury
时间窗: 24 hrs after LPS administration
Inducible NO synthase expression
时间窗: 24 hrs after LPS administration
NO-metabolites
时间窗: 24 hrs after LPS administration
Mediators of Vascular reactivity
时间窗: 24 hrs after LPS administration
Sensitivity to norepinephrine
时间窗: 24 hrs after LPS administration
次要结局
未报告次要终点