Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development in Healthy and Insulin Resistant Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Extracellular potassium concentration meassured with microdialysis
研究概览
简要总结
To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Non smokers
- •HbA1c <38 mmol/mol (<5.7%), HOMA-IR > 1.7 (insulin resistant)
- •VO2max <40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy)
- •BMI >26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy)
排除标准
- •Use of antidiabetic medication or any other medication deemed to interfere with study outcomes
- •Allergy towards Nicorandil
- •Chronic disease other than type 2 diabetes deemed to interfere with study outcomes
- •Excessive alcohol consumption (>14 units/week)
- •Abnormal ECG
研究组 & 干预措施
Healthy subjects
Two experimental day where the effect of Nicorandil (20mg) or placebo will asses the function of the ATP sensitive potassium pumps role in the development of fatigue.
干预措施: Placebo (Drug)
Healthy subjects
Two experimental day where the effect of Nicorandil (20mg) or placebo will asses the function of the ATP sensitive potassium pumps role in the development of fatigue.
干预措施: Nicorandil (Drug)
Insulin resistant
Two experimental day where the effect of Nicorandil (20mg) or placebo will asses the function of the ATP sensitive potassium pumps role in the development of fatigue.
干预措施: Placebo (Drug)
Insulin resistant
Two experimental day where the effect of Nicorandil (20mg) or placebo will asses the function of the ATP sensitive potassium pumps role in the development of fatigue.
干预措施: Nicorandil (Drug)
结局指标
主要结局
Extracellular potassium concentration meassured with microdialysis
时间窗: Changes in potassium handling from the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks
Interstitial potassium
次要结局
- Performance (time to exhaustion) during knee extensor exercise(Changes in performance during the placebo experimental day compared to the experimental days with Nicorandil ingestion with 14 days between each experimental day. Timeframe pr. subject approx. 6 weeks.)
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen