The effect of ingesting carbohydrate drink on stomach size and cardiac flow in healthy volunteers

Not Applicable

• Conditions: cardiac output; gastric volume; Anaesthesiology - Anaesthetics; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12623000178640
• Lead Sponsor: Dr Harsh Dubey

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-02-21
• Last Update Posted: 27 February 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Candidates must be available to attend St Vincent’s Hospital Melbourne for the study to be completed and;
They must be willing to have an ultrasound probe pressed against specific areas of the body, specifically the abdomen and thorax (to be exact the front left chest) and;
They must be willing to fast for 6 hours then ingest carbohydrate-containing liquid drink

Exclusion Criteria

Candidates who decline to have ultrasound investigations performed on their thorax or abdomen; or
Candidates who are trainees or employees of the anaesthetic department of St Vincent's Hospital Melbourne or
Candidates who knowingly have gastric disease or cardiovascular disease (as these conditions will impact the interpretation and usefulness of the results)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in cardiac output (CO) measured by transthoracic echocardiography, specifically the product of stroke volume (SV) and heart rate (HR). This will be a composite primary outcome, the change in the product of SV and HR will give the change in CO. <br>Stroke volume will be determined by non-invasive transthoracic echocardiography (TTE) specifically utilising the left ventricular outflow tract (LVOT) velocity time integral (VTI) and the LVOT diameter. [Immediately after consumption, then 30, 60 and 120 minutes (primary timepoint) after ingestion of the carbohydrate drink. ]

Secondary Outcome Measures

Name	Time	Method
Change in gastric volume. <br>Gastric volume (GV) will be determined by non-invasive gastric ultrasound utilising the gastric antrum cross-sectional area (CSA) and candidate age via the following validated formula:<br>GV (ml) = 27.0 + (14.6 x CSA (cm2)) - 1.28 x age (yr)<br>[Immediately after consumption, then 30, 60 and 120 minutes after ingestion of the carbohydrate drink. ]