Assessment of Sarcopenia, Physical Performance and Cognitive Function in Hemodialysis Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 26
- 主要终点
- Sarcopenia
研究概览
简要总结
Many systems such as the cardiovascular, pulmonary, musculoskeletal, hematological, immunological, gastrointestinal, central nervous system are affected due to decreased kidney function. The aim of this study was to investigate the relationship between physical performance and sarcopenia, peripheral muscle strength, activities of daily living, cognitive functions, physical activity level, fragility, pain in hemodialysis patients.
详细描述
A high prevalence of sarcopenia has been reported in end stage kidney disease. The incidence of sarcopenia increases with age. Muscle atrophy is caused by an imbalance between the anabolic and catabolic processes in chronic kidney disease. Sarcopenia and physical inactivity progress synergistically. Decreased physical performance is associated with sarcopenia. In hemodialysis patients, daily physical activity level and physical performance decrease. Cognitive impairment is common in chronic kidney disease. Uremic toxins can cause a decrease in cognitive function. One of the most important problems associated with hemodialysis is pain and pain negatively affects functional capacity and quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having been diagnosed with end stage kidney disease
- •Receiving hemodialysis for more than 3 months
- •Being clinically stable
- •Volunteering to participate in the research
排除标准
- •Having an orthopedic disease that may affect functional capacity
- •Having cardiac event in the past 3 months
结局指标
主要结局
Sarcopenia
时间窗: 5 minutes
Sarcopenia will be evaluated using SARC-F questionnaire. For SARC-F, a total score of ≥ 4 indicates sarcopenia.
Physical performance will be evaluated using Short physical performance battery.
时间窗: 10 minutes
The total score of Short physical performance battery ranges from 0 to 12.
Physical performance will be evaluated using 1 minute sit to stand test.
时间窗: 5 minutes
1 minute sit to stand test, the maximum number of repetitions within the established time was recorded
Pain level
时间窗: 5 minutes
Pain will be evaluated using Short-form McGill Pain questionnaire
次要结局
- Peripheral muscle strength(5 minutes)
- Physical activity level(5 minutes)
- Activities of daily living(10 minutes)
- Cognitive function(10 minutes)
- Fragility(5 minutes)
研究者
Merve Firat
Principal Investigator
Hacettepe University