Assessment of Sarcopenia, Physical Performance and Cognitive Function in Hemodialysis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- End Stage Kidney Disease
- Sponsor
- Hacettepe University
- Enrollment
- 26
- Primary Endpoint
- Sarcopenia
- Last Updated
- 5 years ago
Overview
Brief Summary
Many systems such as the cardiovascular, pulmonary, musculoskeletal, hematological, immunological, gastrointestinal, central nervous system are affected due to decreased kidney function. The aim of this study was to investigate the relationship between physical performance and sarcopenia, peripheral muscle strength, activities of daily living, cognitive functions, physical activity level, fragility, pain in hemodialysis patients.
Detailed Description
A high prevalence of sarcopenia has been reported in end stage kidney disease. The incidence of sarcopenia increases with age. Muscle atrophy is caused by an imbalance between the anabolic and catabolic processes in chronic kidney disease. Sarcopenia and physical inactivity progress synergistically. Decreased physical performance is associated with sarcopenia. In hemodialysis patients, daily physical activity level and physical performance decrease. Cognitive impairment is common in chronic kidney disease. Uremic toxins can cause a decrease in cognitive function. One of the most important problems associated with hemodialysis is pain and pain negatively affects functional capacity and quality of life.
Investigators
Merve Firat
Principal Investigator
Hacettepe University
Eligibility Criteria
Inclusion Criteria
- •Having been diagnosed with end stage kidney disease
- •Receiving hemodialysis for more than 3 months
- •Being clinically stable
- •Volunteering to participate in the research
Exclusion Criteria
- •Having an orthopedic disease that may affect functional capacity
- •Having cardiac event in the past 3 months
Outcomes
Primary Outcomes
Sarcopenia
Time Frame: 5 minutes
Sarcopenia will be evaluated using SARC-F questionnaire. For SARC-F, a total score of ≥ 4 indicates sarcopenia.
Physical performance will be evaluated using Short physical performance battery.
Time Frame: 10 minutes
The total score of Short physical performance battery ranges from 0 to 12.
Physical performance will be evaluated using 1 minute sit to stand test.
Time Frame: 5 minutes
1 minute sit to stand test, the maximum number of repetitions within the established time was recorded
Pain level
Time Frame: 5 minutes
Pain will be evaluated using Short-form McGill Pain questionnaire
Secondary Outcomes
- Peripheral muscle strength(5 minutes)
- Physical activity level(5 minutes)
- Activities of daily living(10 minutes)
- Cognitive function(10 minutes)
- Fragility(5 minutes)