NCT03171935Unknown不适用
Wean Early With High-Flow Nasal Cannula Oxygenation Versus Noninvasive Positive Pressure Ventilation in Patients With Acute Hypoxemic Respiratory Failure: a Multicenter, Randomized, Controlled Trial (the WHEN Study)
Beijing Chao Yang Hospital1 个研究点 分布在 1 个国家目标入组 270 人开始时间: 2017年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- Duration of invasive mechanical ventilation
研究概览
简要总结
The main purpose of the present study is to verify whether, as compared with conventional weaning, early weaning with high-flow nasal cannula oxygenation or noninvasive positive pressure ventilation may more effective in shortening the duration of invasive ventilation, hence reducing the rates of complications and mortality in patients with acute hypoxemic respiratory failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Orotracheal intubation；
- •PaO2 <60mmHg（venturi mask，FiO2=0.5），and PaCO2 ≤45mmHg；
- •Meeting criteria for weaning readiness；
- •Spontaneous breathing trial failure.
排除标准
- •Duration of invasive ventilation <48h；
- •Tracheotomy；
- •Percentage of cuff leak volume in tidal volume<15.5%；
- •Unable to spontaneously clear secretions from their airway；
- •Recent oral，nasal，facial or cranial trauma or surgery；
- •Recent gastric or esophageal surgery；
- •Active upper gastro-intestinal bleeding；
- •Severe abdominal distension；
- •Lack of co-operation；
- •Chronic respiratory disease such as chronic obstructive pulmonary disease, asthma, interstitial lung disease and neuromuscular disease.
结局指标
主要结局
Duration of invasive mechanical ventilation
时间窗: 2.5 years
次要结局
未报告次要终点
研究者
Zujin Luo
MD
Beijing Chao Yang Hospital
研究点 (1)
Loading locations...
相似试验
已完成
不适用
HFNC for Induction During Bariatric Surgery Patients.Lung CollapseNCT03155711Fundación para la Investigación del Hospital Clínico de Valencia64
已完成
不适用
Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography StudyAdult Patients Ventilated More Than 48 hStable Respiratory and Hemodynamic Conditions for SBTConsent of PatientsArterial LineNCT01702779University Hospital, Clermont-Ferrand80
已完成
不适用
High-flow Nasal Cannula Oxygen Versus Conventional Oxygen Therapy After Pulmonary LobectomyRespiratory InsufficiencyLung CancerNCT02544477Catholic University of the Sacred Heart94
Unknown
不适用
Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical TrialTraumatic Lung InjuryNCT05509088Ain Shams University120
已完成
不适用
Comparison of HFNC With NIV in Weaning COPDChronic Obstructive Pulmonary Disease With (Acute) ExacerbationNCT03458364Jie Li42