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Clinical Trials/NCT01702779
NCT01702779CompletedNot Applicable

Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

University Hospital, Clermont-Ferrand1 site in 1 country80 target enrollmentStarted: August 1, 2011Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
80
Locations
1
Primary Endpoint
variations of lung ultrasound score
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Detailed Description

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Adult patients ventilated more than 48 h
  • •Stable respiratory and hemodynamic conditions for SBT
  • •Consent of patients
  • •Arterial line

Exclusion Criteria

  • •Laryngeal dyspnea
  • •Tracheostomy
  • •No echogenicity
  • •Paraplegia >T8

Outcomes

Primary Outcomes

variations of lung ultrasound score

Time Frame: 24 hours after extubation

Secondary Outcomes

  • Lung ultrasound score(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)
  • rates of patients with postextubation distress(during the 48th post-extubation)
  • Electrical Impedance tomography(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)
  • Epithelial and endothelial biomarkers(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)

Investigators

Sponsor
University Hospital, Clermont-Ferrand
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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