Multizentre observational study for treatment of children and adolescents with mature B-cell Non-Hodgkin-Lymphoma/leukemia
- Conditions
- C85Other and unspecified types of non-Hodgkin lymphoma
- Registration Number
- DRKS00009436
- Lead Sponsor
- Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen, Abteilung Pädiatrische Hämatologie und Onkologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 863
Inclusion Criteria
newly diagnosed mature B-NHL or B-ALL
informed consent of patient/guardian
start of therapy within recruting period of study
treatment in a participating centre of study
no participation in a concurrend clinical trial
no evidence of pregnancy
effective contraception
Exclusion Criteria
previous malignancy
severe immunondeficiency
HIV/AIDS
previous organ transplantation
preexisting disease prohibiting chemotherapy as per protocol
significant cytoreductive pre-treatment
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method probability of event-free survival from diagnosis until one year after diagnosis. Events are: recurrence, secondary malignancies or death from any cause
- Secondary Outcome Measures
Name Time Method toxicity according to NCI criteria particularly of intensified intrathecal therapy in CNS-positive patients during chemotherapy until one month after chemotherapy