Effects of intravenous autologous bone marrow derived mesenchymal stem cells in patients with chronic heart failure
Not Applicable
- Conditions
- chronic heart failure
- Registration Number
- JPRN-UMIN000025233
- Brief Summary
The procedure did not induce significant changes in vital signs. One patient had an elevated body temperature after 1 day, but recovered spontaneously. Laboratory tests remained normal for 1 month after cell delivery. Computed tomography was performed after 1-2 years, and there was no evidence of malignancy. In this pilot study of patients with reduced LVEF, intravenous MSC delivery had no adverse effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
Not provided
Exclusion Criteria
1.Unstable heart failure 2.Patients with unstable angina 3.Current cardiac surgery and device therapy 4.Life expectancy less than 6 months 5.Severe liver and kidney failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of left ventricular ejection fraction on echocardiography
- Secondary Outcome Measures
Name Time Method change of BNP and high sensitive troponin