The role of chimerism in organ transplantatio
Not Applicable
- Conditions
- Kidney allograft recipients.Unspecified renal failure
- Registration Number
- IRCT201106266876N1
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Being the case of first renal transplantion
Exclusion criteria: Previous transfusion; retransplantation; cardiovascular diseases; having genetic diseases and morbid obesity.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum creatinine levels. Timepoint: Weekly in first 3 month and then monthly during two years follow-up. Method of measurement: Colorimetric method (Jaffe).;Microchimerism quantification. Timepoint: Weeks: 1 and 2; months: 1, 3, 6 and 12. Method of measurement: Real-time PCR.;Acute rejection episodes. Timepoint: During 6 months after transplantation. Method of measurement: Clinical evaluation and biopsy protocol.
- Secondary Outcome Measures
Name Time Method SCD30. Timepoint: Days: 4, 14 and 30 after transplant. Method of measurement: ELISA method.;Anti-HLA antibodies. Timepoint: Second week; months: 1 and 3. Method of measurement: ELISA method.;Sera cytokines (IL-10 and IFN-g). Timepoint: Days: 10 and 14 after transplant. Method of measurement: ELISA method.