ISRCTN43245574已完成2 期
Anti-platelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease
ewcastle upon Tyne Hospitals NHS Foundation Trust0 个研究点目标入组 120 人开始时间: 2015年10月21日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
研究概览
简要总结
2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29804061 protocol (added 17/05/2019) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31403053/ (added 08/11/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 18 years or over
- •2. Abnormal spirometry with FEV1<80% and FEV1/FVC ratio <70% of predicted
- •3. Smoking history that is 10 years or greater (current or ex smokers can be included)
- •4. Patient has the capacity to consent
排除标准
- •1. Any condition that is being concurrently treated through anticoagulation or antiplatelet therapy (atrial fibrillation, deep vein thrombosis, valve prosthesis, recent myocardial infarction, use of drug eluting stents)
- •2. Other specific contraindications to management with antiplatelet medication (bleeding risks, allergies)
- •3. Any contraindication for Aspirin and Ticagrelor use
- •4. Other concurrent terminal illnesses with life expectancy less than 1 year (congestive cardiac failure, carcinoma etc.)
- •5. Current involvement in another clinical trial or exposure to another IMP within the previous 30 days
- •6. COPD with an atypical cause (e.g. A1antitrypsin deficiency)
- •7. Planned/ Expected major surgery where anti-platelet therapy would be ceased
- •8. Pregnancy, planned pregnancy or current breastfeeding
- •9. Patient is unable to provide informed consent
- •10. Younger than 18 years
研究者
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