EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan
- Conditions
- Congestive Heart Failure
- Registration Number
- NCT00071331
- Brief Summary
The purpose of this study is to compare the effectiveness of tolvaptan or placebo in adults with worsening congestive heart failure (CHF).
- Detailed Description
Study Design: Multicenter, randomized, double-blind, placebo-controlled
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3600
- Age greater than or equal to 18 years.
- Current hospitalization for chronic congestive heart failure with admission up to 48 hours prior to randomization. Chronic heart failure is defined as requiring treatment for a minimum of 30 days prior to hospitalization.
The subject must have signs of extracellular volume expansion, defined as two or more of the following: a) jugular venous distention; b) pitting edema (>1+); or c) dyspnea.
- NYHA Class III or IV at the time of hospitalization.
- Left Ventricular Ejection Fraction < = 40% within one year.
Exclusion Criteria
- Women who will not adhere to the reproductive precautions as outlined in the Informed Consent form.
- Positive urine pregnancy test.
- Inability to provide written informed consent.
- Cardiac surgery within 60 days of potential study enrollment, excluding percutaneous coronary interventions.
- Planned revascularization procedures, electrophysiologic (EP) device implantation, cardiac mechanical support implantation, cardiac transplantation, or other cardiac surgery within 30 days following study enrollment.
- Subjects who are on cardiac mechanical support.
- History of bi-ventricular pacer placement within the last 60 days.
- Co-morbid condition with an expected survival less than six months.
- Subjects with acute ST segment elevation myocardial infarction at the time of hospitalization.
- History of sustained ventricular tachycardia or ventricular fibrillation within 30 days, unless in the presence of an automatic implantable cardioverter defibrillator.
- History of a cerebrovascular accident within the last 30 days.
- Hemodynamically significant uncorrected primary cardiac valvular disease.
- Hypertrophic cardiomyopathy (obstructive or non-obstructive).
- CHF due to uncorrected thyroid disease, active myocarditis or known amyloid cardiomyopathy.
- Subjects with progressive or episodic neurological disease such as multiple sclerosis or history of multiple strokes.
- History of primary significant liver disease or acute hepatic failure, as defined by the investigator.
- History of poorly controlled diabetes mellitus.
- Morbid obesity, defined as > 159 kg (or 350 lbs) or BMI > 40.
- Supine systolic arterial blood pressure < 90 mmHg.
- Serum creatinine > 3.5 mg/dL or > 309.4 mmol/L.
- Serum potassium > 5.5 mEq/L or > 5.5 mmol/L.
- Hemoglobin < 9 g/dL or < 90 g/L.
- History of hypersensitivity and/or idiosyncratic reaction to benzazepine derivatives (such as benazapril).
- History of drug or medication abuse within the past year, or current alcohol abuse.
- Inability to take oral medications.
- Participation in another clinical drug or device trial within the past 30 days.
- Previous participation in this or any other tolvaptan clinical trial.
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (355)
Hjertemed.avd. Akershus Universitetssykenhus
🇳🇴Nordbyhagen, Norway
Diakonhjemmets sykehus Oslo
🇳🇴Oslo, Norway
The Heart and Vascular Institute of Florida
🇺🇸St. Petersburg, Florida, United States
LAC/USC Medical Center
🇺🇸Los Angeles, California, United States
VA Medical Center- W. Los Angeles
🇺🇸Los Angeles, California, United States
Melbourne Internal Medicine Assoc.
🇺🇸Melbourne, Florida, United States
Pitt County Memorial Hospital, The Heart Center
🇺🇸Greenville, North Carolina, United States
Guthrie Clinic, LTD
🇺🇸Sayre, Pennsylvania, United States
Clinical Research Limited
🇺🇸Canton, Ohio, United States
Cardiology Consultants of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Invascor Clinical Research
🇨🇦Longueuil, Quebec, Canada
The Heart Center
🇺🇸Huntsville, Alabama, United States
Cardiology Associates
🇺🇸Larkspur, California, United States
Mission Internal Medical Group
🇺🇸Mission Viejo, California, United States
Phoenix Memorial Hospital
🇺🇸Gilbert, Arizona, United States
Central Cardiology Medical Center
🇺🇸Bakersfield, California, United States
Florida Cardiovascular Research
🇺🇸Atlantis, Florida, United States
Cardiology Research Associates
🇨🇦Scarborough, Ontario, Canada
Cardiovascular Center of Sarasota
🇺🇸Sarasota, Florida, United States
ARI Clinical Trials
🇺🇸Redondo Beach, California, United States
Heart and Vascular Clinic of North Colorado
🇺🇸Fort Collins, Colorado, United States
Illinois Heart & Lung Associates
🇺🇸Normal, Illinois, United States
Ocala Resarch Institute
🇺🇸Ocala, Florida, United States
North Shore Cardiologists
🇺🇸Bannockburn, Illinois, United States
MidAtlantic Cardiovascular Associates
🇺🇸Westminster, Maryland, United States
Midatlantic Cardiovascular Associates
🇺🇸Bel Air, Maryland, United States
Shore Health System
🇺🇸Easton, Maryland, United States
Midwest Heart Research Found.
🇺🇸Lombard, Illinois, United States
Bakersfield Memorial Hospital
🇺🇸Bakersfield, California, United States
The Heart Group
🇺🇸Mobile, Alabama, United States
Pacific Heart Institute
🇺🇸Santa Monica, California, United States
Atlanta Heart and Vascular Research Group
🇺🇸Atlanta, Georgia, United States
Jacksonville Heart Center
🇺🇸Jacksonville, Florida, United States
Cardiology Associates of Fort Lauderdale
🇺🇸Fort Lauderdale, Florida, United States
Asheville Cardiology Associates
🇺🇸Asheville, North Carolina, United States
Michigan Heart
🇺🇸Ypsilanti, Michigan, United States
St. Lukes-Roosevelt Hospital Centers
🇺🇸New York, New York, United States
The Care Group
🇺🇸Indianapolis, Indiana, United States
Missouri Cardiovascular Specialists
🇺🇸Columbia, Missouri, United States
St. Louis University
🇺🇸St. Louis, Missouri, United States
Mid Carolina Cardiology
🇺🇸Charlotte, North Carolina, United States
Park Nicollet Heart Center
🇺🇸St. Louis Park, Minnesota, United States
Regions Hospital Cardiology Research
🇺🇸St. Paul, Minnesota, United States
The Louisiana Heart Center
🇺🇸Chalmette, Louisiana, United States
Primary Care Cardiology Research
🇺🇸Ayer, Massachusetts, United States
Beaumont Hospital
🇺🇸Troy, Michigan, United States
Cardiovascular Associates
🇺🇸Kingsport, Tennessee, United States
Hospital Privado Antartida
🇦🇷Capital Federal, Argentina
Mid America Cardiology
🇺🇸Kansas City, Kansas, United States
St. Vincents Hospital and Medical Center
🇺🇸New York, New York, United States
Covenant Medical Center
🇺🇸Saginaw, Michigan, United States
Albany Associates in Cardiology
🇺🇸Albany, New York, United States
St. Francis Hospital
🇺🇸Roslyn, New York, United States
Cardiac Centers of LA, LLC
🇺🇸Shreveport, Louisiana, United States
Leonard J Chabert Medical Center
🇺🇸Houma, Louisiana, United States
St. Paul Heart Clinic
🇺🇸St. Paul, Minnesota, United States
SUNY
🇺🇸Syracuse, New York, United States
Heart Associates, P.A.
🇺🇸Towson, Maryland, United States
Northwest Ohio Cardiology Consultants
🇺🇸Toledo, Ohio, United States
Buxmont Cardiology Associates, PC
🇺🇸Sellersville, Pennsylvania, United States
Hendersonville Cardiology
🇺🇸Hendersonville, North Carolina, United States
Cleveland Cardiovascular Research
🇺🇸Fairview Park, Ohio, United States
North Ohio Research Limited
🇺🇸Sandusky, Ohio, United States
The Dayton Heart Center
🇺🇸Dayton, Ohio, United States
Akron General Medical Center
🇺🇸Akron, Ohio, United States
Sterling Research Group
🇺🇸Cincinnati, Ohio, United States
Cardiology Associates of West Reading
🇺🇸West Reading, Pennsylvania, United States
Santa Casa de Misericordia do Rio de Janeiro
🇧🇷Rio de Janeiro, RJ, Brazil
South Carolina Heart Center
🇺🇸Columbia, South Carolina, United States
Cardiopulmonary Research Science and Technology Institute
🇺🇸Dallas, Texas, United States
Cardiology Associates Covenant Medical Group
🇺🇸Lubbock, Texas, United States
Hospital das Clinicas da Universidade Federal de Goias
🇧🇷Goiania, GO, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, RS, Brazil
Hopital Louis Pradel
🇫🇷Bron cedex, France
Hospital Fernandez
🇦🇷Capital Federal, Argentina
University Health Network, Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Hospital Evangelico de Curitiba
🇧🇷Curitiba, PR, Brazil
Hospital Governador Israel Pinheiro
🇧🇷Belo Horizonte, MG, Brazil
The Cardiovascular Group PC
🇺🇸Fairfax, Virginia, United States
Klinikum Augsburg
🇩🇪Augsburg, Germany
AZ Middelheim
🇧🇪Antwerpen, Belgium
Greater Niagara General Hospital
🇨🇦Niagara Falls, Ontario, Canada
Scarborough Cardiology Research
🇨🇦Scarborough, Ontario, Canada
Santa Casa de Misericordia de Belo Horizonte
🇧🇷Belo Horizonte, MG, Brazil
Hospital Santa Isabel da Santa Casa de Misericordia da Bahia
🇧🇷Salvador, BA, Brazil
Brampton Research Associates
🇨🇦Brampton, Ontario, Canada
Centre Hospitalier Regional d'Arras-Service de Cardiologie
🇫🇷Arras, France
Fundacao Bahiana de Cardiologia- Hospital Universitario Professor Edgard Santos
🇧🇷Salvador, BA, Brazil
Centre Hospitalier Jeanne d'Arc
🇫🇷Bar-le-Duc, France
St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
Hospital Universitario Onofre Lopes
🇧🇷Natal, Brazil
Klinikum der Medizinischen Fakultat
🇩🇪Halle, Germany
Vivantes Klinikum Neukoln
🇩🇪Berlin, Germany
Universitatsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Ospedale Nigaurda Ca Granda
🇮🇹Milano, Italy
IRCCS Policlinico S. Matteo
🇮🇹Pavia, Italy
Cabinet de Cardiologie et d'Explorations
🇫🇷Essey lès Nancy Cedex, France
Centre Hospitalier
🇫🇷Langres, France
CHU Montpellier
🇫🇷Montpellier, France
Universitatsklinikum Eppendorf
🇩🇪Hamburg, Germany
Friedrich Schiller Universitat Jena
🇩🇪Jena, Germany
Groupe Hospitalier Rangueil-Larrey CHU
🇫🇷Toulouse, France
Hopital General Henri Duffaut
🇫🇷Avignon, France
Herz- und Gefabklinik Bad Neustadt
🇩🇪Bad Neustadt-Saale, Germany
Universitatsklinik Essen
🇩🇪Essen, Germany
Ospedale Civile
🇮🇹Capri, Italy
Akademisches Lehrkrankenhaus d. HGS Essen
🇩🇪Essen, Germany
IRCCS- Fondazione Salvatore Maugeri
🇮🇹Pavia, Italy
Klinikum der Universitat zu Koln
🇩🇪Koln, Germany
Medizinische Universitätsklinik
🇩🇪Heidelberg, Germany
University Leipzig
🇩🇪Leipzig, Germany
Canisius-Wilhelmina Ziekenhuis
🇳🇱Nijmegen, Netherlands
Forskiningsenheten,
🇸🇪Molndal, Sweden
Enheten for internmedicin, Karolinska Institutet
🇸🇪Stockholm, Sweden
Hjartkliniken, M84
🇸🇪Stockholm, Sweden
Hospital de Cruces
🇪🇸Bilbao, Spain
Hospital de Torrecardenas
🇪🇸Almeria, Spain
Military Medical Academy
🇷🇺St. Petersburg, Russian Federation
Leeds General Infirmary
🇬🇧Leeds, United Kingdom
Avd. for intermedicin
🇸🇪Gothenburg, Sweden
Hjartcentrum,
🇸🇪Umea, Sweden
Scunthorpe General Hospital
🇬🇧Scunthorpe, United Kingdom
The Western Pennsylvania Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Beth Israel Medical Center
🇺🇸Boston, Massachusetts, United States
Oddzial Kardiologiczny
🇵🇱Plock, Poland
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
Jacksonville Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Charlotte Heart Group Research Center
🇺🇸Port Charlotte, Florida, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Heart Care Midwest
🇺🇸Peoria, Illinois, United States
Cardiac Disease Specialists PC
🇺🇸Atlanta, Georgia, United States
Georgia Heart Specialists
🇺🇸Covington, Georgia, United States
Nisus Research
🇺🇸Petoskey, Michigan, United States
William Beaumont Hospital
🇺🇸Royal Oak, Michigan, United States
Cardiology Associates, P.C.
🇺🇸Johnson City, New York, United States
Buffalo Cardiology and Pulmonary Associates
🇺🇸Williamsville, New York, United States
South Bay Cardiovascular Associates
🇺🇸West Islip, New York, United States
Alamance Regional Medical Center
🇺🇸Burlington, North Carolina, United States
Midwest Cardiology Research Foundation
🇺🇸Columbus, Ohio, United States
Southeast Texas Cardiology Associates
🇺🇸Beaumont, Texas, United States
University of Texas Medical Branch
🇺🇸Galveston, Texas, United States
McAllen Heart Clinic
🇺🇸McAllen, Texas, United States
Scott & White Clinic Division of Cardiology
🇺🇸Temple, Texas, United States
University of Virginia Medical Center
🇺🇸Charlottesville, Virginia, United States
Inova Institute of Research
🇺🇸Falls Church, Virginia, United States
Roanoke Heart Institute
🇺🇸Roanoke, Virginia, United States
Empire Health Services
🇺🇸Spokane, Washington, United States
Rockwood Clinic
🇺🇸Spokane, Washington, United States
Wisconsin Center For Clinical Research
🇺🇸Elkhorn, Wisconsin, United States
Clinica Constituyentes de Moron
🇦🇷Buenos Aires, Argentina
Hospital Churruca
🇦🇷Buenos Aires, Argentina
Hospital Eva Peron
🇦🇷Buenos Aires, Argentina
Instituto de Cardiologia J. F. Cabral
🇦🇷Corrientes, Argentina
Instituto do Coracao do Hospital das Clinicas- Faculdade de Medicina da Universidade de Sao Paulo
🇧🇷Sao Paulo, SP, Brazil
Hospital das ClÃnicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
The Scarborough Hospital
🇨🇦Toronto, Ontario, Canada
Lakeridge Health Oshawa
🇨🇦Oshawa, Ontario, Canada
Interni oddeleni
🇨🇿Usti nad Labem, Czech Republic
Centre Hospitalier de l'Universite de Sherbrooke
🇨🇦Fleurimond, Quebec, Canada
Centre Cardiologique du Nord
🇫🇷Saint Denis, France
Herzzentrum Bad Krozingen
🇩🇪Bad Krozingen, Germany
Georg-August-Universitat Gottingen
🇩🇪Gottingen, Germany
Ospedale Civile S. Giuseppe
🇮🇹Albano Laziale, Italy
Centro Cardiologico Monzino
🇮🇹Milano, Italy
Azienda USL n. 6 Ospedale Civile
🇮🇹Cecina, Italy
Fondazione Salvatore Maugeri
🇮🇹Montescano, Italy
Moscow Medical Academy
🇷🇺Moscow, Russian Federation
St. Petersburg Clinical Hospital of Russian Academy of Sciences
🇷🇺St. Petersburg, Russian Federation
Hospital Clinic y Provincial
🇪🇸Barcelona, Spain
Hospital Reina Sofia, in Cordoba
🇪🇸Cordoba, Spain
Hospital Doce de Octubre
🇪🇸Madrid, Spain
Hospital Severo Ochoa
🇪🇸Madrid, Spain
Hospital Universitari de Tarragona Joan XXIII
🇪🇸Tarragona, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Kardiologkliniken
🇸🇪Stockholm, Sweden
Cardiocentro Ticino
🇨ðŸ‡Lugano, Switzerland
Cardiologkliniken, Avd 50F
🇸🇪Uppsala, Sweden
Bradford Royal Infirmary
🇬🇧Bradford, United Kingdom
Northern Manchester General Hospital
🇬🇧Manchester, United Kingdom
University of Miami/ Jackson Memorial Hospital
🇺🇸Miami, Florida, United States
Miami Research and Education Foundation
🇺🇸Miami, Florida, United States
The Lindner Clinical Trial Center
🇺🇸Cincinnati, Ohio, United States
San Diego Cardiac Center
🇺🇸San Diego, California, United States
Hennepin County Medical Center
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Durham VA Medical Center
🇺🇸Durham, North Carolina, United States
Duke Cardiology Research
🇺🇸Durham, North Carolina, United States
University of Texas Health Science Center
🇺🇸San Antonio, Texas, United States
Wilford Hall Medical Center,
🇺🇸San Antonio, Texas, United States
Vanderbilt Clinical Trials Center
🇺🇸Nashville, Tennessee, United States
VA Salt Lake City Health Care System
🇺🇸Salt Lake City, Utah, United States
St. Boniface General Hospital
🇨🇦Winnipeg, Manitoba, Canada
New York Presbyterian Hospital
🇺🇸New York, New York, United States
Arizona Heart Institute
🇺🇸Phoenix, Arizona, United States
John Dingell VA Medical Center
🇺🇸Detroit, Michigan, United States
Integris Heart Research Center
🇺🇸Oklahoma City, Oklahoma, United States
Nordlandsykehuset
🇳🇴Bodo, Norway
Cardiology Associates of North Mississippi
🇺🇸Tupelo, Mississippi, United States
Christiana Care Health System
🇺🇸Newark, Delaware, United States
Bryan LGH Heart Institute
🇺🇸Lincoln, Nebraska, United States
Minneapolis Heart Institute
🇺🇸Minneapolis, Minnesota, United States
Northeast Cardiology Associates
🇺🇸Bangor, Maine, United States
Maine Medical Center
🇺🇸Portland, Maine, United States
Morristown Memorial Hospital
🇺🇸Morristown, New Jersey, United States
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
Bakus Resesarch
🇺🇸Norwich, Connecticut, United States
Hospital Italiano de Buenos Aires
🇦🇷Capital Federal, Argentina
Sanatorio Municipal "Julio A. Mendez"
🇦🇷Capital Federal, Argentina
Lousiana State University Health Sciences Center
🇺🇸Shreveport, Louisiana, United States
I. interni kardio-angiologicka klinika LF MU
🇨🇿Brno, Czech Republic
Interni klinika IPVZ
🇨🇿Zlin, Czech Republic
Gelre Ziekenhuis (location Juliana)
🇳🇱Apeldoorn, Netherlands
Ziekenhuis Gooi Noord
🇳🇱Blaricum, Netherlands
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada
University of Medicine and Dentistry of New Jersey
🇺🇸Newark, New Jersey, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Peter Loougheed Center
🇨🇦Calgary, Alberta, Canada
Idaho Cardiology Associates
🇺🇸Meridian, Idaho, United States
Hospital Argerich
🇦🇷Buenos Aires, Argentina
Hospital Privado Centro Medico de Cordoba
🇦🇷Cordoba, Argentina
Hospital Central de San Isidro
🇦🇷San Isidro, Argentina
I.Interni oddeleni
🇨🇿Praha, Czech Republic
Klinika kardiologie
🇨🇿Praha, Czech Republic
North Shore University Hospital
🇺🇸Manhasset, New York, United States
Northshore Medical Research
🇺🇸Covington, Louisiana, United States
Hospital de Clinicas
🇦🇷Capital Federal, Argentina
Policlinica Bancaria
🇦🇷Capital Federal, Argentina
Hospital Italiano de Cordoba
🇦🇷Cordoba, Argentina
Hospital Militar de Cordoba
🇦🇷Cordoba, Argentina
Clinique St Elisabeth Place Louise
🇧🇪Namur, Belgium
Cliniques UCL Mont-Godinne
🇧🇪Yvoir, Belgium
Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
Hotel-Dieu de Saint-Jerome
🇨🇦Saint Jerome, Quebec, Canada
Interni klinika, Oddeleni Interna I, Kardiologie
🇨🇿Pardubice, Czech Republic
Kardiologicka klinika
🇨🇿Praha, Czech Republic
The Chattanooga Heart Institute
🇺🇸Chattanooga, Tennessee, United States
Stern Cardiovascular Center
🇺🇸Memphis, Tennessee, United States
Androscoggin Cardiology Associates
🇺🇸Auburn, Maine, United States
Garden State Cardiology
🇺🇸Paramus, New Jersey, United States
Clinica Modelo de Moron
🇦🇷Buenos Aires, Argentina
Hospital Ramos Mejia
🇦🇷Capital Federal, Argentina
Hospital Allende
🇦🇷Cordoba, Argentina
AZ Imelda Ziekenhuis
🇧🇪Bonheiden, Belgium
CAMC Clinical Trials
🇺🇸Charleston, West Virginia, United States
Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
Kardiologicke oddeleni
🇨🇿Praha, Czech Republic
The Cardiology Group
🇺🇸Tullahoma, Tennessee, United States
Victoria Heart Institute Foundation
🇨🇦Victoria, British Columbia, Canada
Surrey Memorial Hospital
🇨🇦Surrey, British Columbia, Canada
Fundacion Favaloro
🇦🇷Buenos Aires, Argentina
Hospital Nacional Dr. Alejandro Posadas
🇦🇷Buenos Aires, Argentina
Ziekenhuis Gelderse Vallei
🇳🇱Ede, Netherlands
I.Interni klinika
🇨🇿Plzen-Lochotin, Czech Republic
II.Interni klinika
🇨🇿Praha, Czech Republic
Hjerte med. Avd. Haukeland Universitets Sykehus
🇳🇴Bergen, Norway
Med. Avd. Sykenhuset Telemark
🇳🇴Skien, Norway
Spitalul Universitar de Urgenta Bucuresti
🇷🇴Bucharest, Romania
Spitalul Clinic Universitar ,,Sf. Spiridon"
🇷🇴Iasi, Romania
Health Sciences Center
🇨🇦St. John's, Newfoundland and Labrador, Canada
Burdenko Main Military Clinical Hospital
🇷🇺Moscow, Russian Federation
Central Clinical Hospital Presidential
🇷🇺Moscow, Russian Federation
Ziekenhuis Hilversum
🇳🇱Hilversum, Netherlands
Sint Lucas Andreas Ziekenhuis (loc. Lucas)
🇳🇱Amsterdam, Netherlands
Medisch Centrum Haaglanden (location Westeinde)
🇳🇱Den Haag, Netherlands
Oosterschelde Ziekenhuizen
🇳🇱Goes, Netherlands
Martini Ziekenhuis (Loc. Martini Paviljoen)
🇳🇱Groningen, Netherlands
Oddzial Kardiologii
🇵🇱Wloclawek, Poland
Institutul de Boli Cardiovasculare
🇷🇴Bucharest, Romania
I Klinika Choroby Wiencowej
🇵🇱Warszawa, Poland
Spitalul Caritas, Clinica Medicala
🇷🇴Bucharest, Romania
Institutul Inimii, Prof.N. Stancioiu
🇷🇴Cluj-Napoca, Romania
Botkins Moscow City Hospital
🇷🇺Moscow, Russian Federation
Spitalul Universitar de Urgenta
🇷🇴Bucuresti, Romania
Centrul de Cardiologie Craiova
🇷🇴Craiova, Romania
Jeroen Bosch Ziekenhus (location Groot Ziekengasthius=GZG)
🇳🇱Den Bosch, Netherlands
Isala Klinieken (Loc. Sophia)
🇳🇱Zwolle, Netherlands
Stavanger Helseforskning
🇳🇴Stavanger, Norway
Oddzial Chorob Wewnetrznych
🇵🇱Olawa, Poland
Katedra i Klinika Chorab Wewnetrznych i Kardiologii
🇵🇱Warszawa, Poland
Spitalul Judetean Brasov, Sectia de Cardiologie
🇷🇴Brasov, Romania
Spitalul de Urgenta Floreasca, Clinica de Cardiologie
🇷🇴Bucharest, Romania
Deventer Ziekenhuis
🇳🇱Deventer, Netherlands
Medisch Spectrum Twente
🇳🇱Enschede, Netherlands
Spaarne Ziekenhuis
🇳🇱Heemstede, Netherlands
Katedra i Oddzial Kliniczny Kardiologii Slaskiej Akademii
🇵🇱Tychy, Poland
Institutul de Boli Cardiovasculare Timisoara
🇷🇴Timisoara, Romania
City Alexandrovsky Hospital, ICU Department
🇷🇺St. Petersburg, Russian Federation
St. Petersburg Dzanelidze State Scientific Research Institute for Emergency Medical Care
🇷🇺St. Petersburg, Russian Federation
St. Petersburg Medical Postgraduate Academy
🇷🇺St. Petersburg, Russian Federation
Cardiology Research Center
🇷🇺Moscow, Russian Federation
Spitalul Clinic Judetean Mures
🇷🇴Targu-Mures, Romania
City Clinical Hospital 2
🇷🇺Moscow, Russian Federation
Moscow Regional Research Clinical Institute n.a. Vishnevsky
🇷🇺Moscow, Russian Federation
Medical Center of General Management
🇷🇺Moscow, Russian Federation
St. Petersburg State University
🇷🇺St. Petersburg, Russian Federation
Moscow State University of Medicine and Dentistry - City Hospital #40
🇷🇺Moscow, Russian Federation
City Hospital #31
🇷🇺St. Petersburg, Russian Federation
City Hospital 8
🇷🇺St. Petersburg, Russian Federation
Veterans Hospital #3
🇷🇺Moscow, Russian Federation
Cardiology Research Institute of the Ministry of Health of the Russian Federation
🇷🇺St. Petersburg, Russian Federation
St. Elisabeth City Hospital
🇷🇺St. Petersburg, Russian Federation
Medicinkliniken
🇸🇪Goteborg, Sweden
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Aurora Denver Cardiology Associates
🇺🇸Denver, Colorado, United States
University of Colorado
🇺🇸Denver, Colorado, United States
Mayo Clinic, Division of Cardiology
🇺🇸Rochester, Minnesota, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Presidio Ospedaliero Villa Sofia
🇮🇹Palmero, Italy
Azienda Ospedaliera S. Michele
🇮🇹Cagliari, Italy
Poliambulatorio Valdichiana Ospedale di Cortona
🇮🇹Cortona, Italy
Ospedali Riunti
🇮🇹Parma, Italy
Ospedale S. Maria delle Grazie
🇮🇹Pozzuoli, Italy
Ospedale S. Bartolomeo
🇮🇹Sarzana, Italy
Ospedali Civile SS Annunziata
🇮🇹Sassari, Italy
Centre Hospitalo-Universitaire de Nantes-Service de Cardiologie
🇫🇷Nantes Cedex, France
Hopital Pasteur
🇫🇷Nice, France
Centre Hospitalier Universitaire de Nancy-Brabois
🇫🇷Vandoeuvre les Nancy, France
Hospital Nossa Senhora das Gracas
🇧🇷Curitiba, PR, Brazil
Hospital Nossa Senhora da Conceica
🇧🇷Porto Alegre, RS, Brazil
Hospital de Base da Faculdade de Medicina de Sao Jose do Rio Preto
🇧🇷Sao Jose de Rio Preto, SP, Brazil
IMC- Instituto de Molestias Cardiovasculares
🇧🇷Sao Jose do Rio Preto, SP, Brazil
Hospital e Maternidade Celso Pierro
🇧🇷Campinas, SP, Brazil
Hospital Universitario Pedro Ernesto
🇧🇷Rio de Janeiro, Brazil
Heart Consultants
🇺🇸Omaha, Nebraska, United States
Herz- und Diabetes Zentrum Nordrhein-Westfalen
🇩🇪Oeyenhausen, Germany
Robert-Bosch-Krankenhaus
🇩🇪Stuttgart, Germany
Universitatsklinikum der
🇩🇪Greifswald, Germany
Universitatsklinikum Munster
🇩🇪Munster, Germany
Universitat Regensburg
🇩🇪Regensburg, Germany
Universitatsklinikum des Saarland
🇩🇪Homburg/Saar, Germany
Cardiovascular Consultants Medical Group, Inc.
🇺🇸Walnut Creek, California, United States
CHRDL
🇨🇦Joliette, Quebec, Canada
Institute of Physico-Chemical Medicine
🇷🇺Moscow, Russian Federation
Moscow State University of Medicine and Dentistry
🇷🇺Moscow, Russian Federation
Russian State Medical University
🇷🇺Moscow, Russian Federation
Irmandade da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, RS, Brazil
Marienkrankenhaus Soest
🇩🇪Soest, Germany
Oklahoma Cardiovascular Research Group
🇺🇸Oklahoma City, Oklahoma, United States
VA Medical Center
🇺🇸Washington, District of Columbia, United States
Louisville Cardiology Medical Group
🇺🇸Louisville, Kentucky, United States
VA Medical Center- Kansas City
🇺🇸Kansas City, Missouri, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Ralph H. Johnson VAMC
🇺🇸Charleston, South Carolina, United States
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Austin Cardiovascular Associates
🇺🇸Austin, Texas, United States
Medical College of Virginia
🇺🇸Richmond, Virginia, United States
Cardiovascular Associates of Virginia
🇺🇸Richmond, Virginia, United States
Saguaro Clinical Research
🇺🇸Tucson, Arizona, United States
Central Arkansas Veterans Healthcare Systems
🇺🇸Little Rock, Arkansas, United States
Baptist Clinical Research Center
🇺🇸Memphis, Tennessee, United States
New England Heart Institute
🇺🇸Manchester, New Hampshire, United States
Moscow State University of Medicine and Dentistry - City Hospital #11
🇷🇺Moscow, Russian Federation
Castle Hill Hospital
🇬🇧Cottingham, United Kingdom
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States