NCT02751060Enrolling By Invitation不适用
Evaluation of Plasma Non-coding RNAs (miRNA-320a) as Biomarkers of Diagnosis, Prognosis and Treatment Effects in Coronary Heart Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- the plasma expression of miR-320a in coronary heart disease patients compared to control patients
研究概览
简要总结
The purpose of this study is to determine whether the expression level of miR-320a are effective as biomarker in evaluating the diagnosis, prognosis and treatment effects of coronary heart disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years of age or older;
- •the most recent symptoms of coronary heart disease within 7 days;
- •meet one of the following conditions: A. clinical history of typical ischemic chest pain (more than 5 minutes of persistent chest pain); B. serum cardiac biomarkers positive (TnT/I or creatine kinase peak greater than 99% of URL); C. Electrocardiogram changes of myocardial ischemia.
排除标准
- •pregnant women or plan to;
- •participate in any drug clinical trials within 3 months;
- •patients with life-threatening complications, or the researchers determined that the survival time of patients with no more than 1 years;
- •serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients);
- •previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix);
- •patients refused to comply with the requirements of this study to complete the research work;
- •according to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).
结局指标
主要结局
the plasma expression of miR-320a in coronary heart disease patients compared to control patients
时间窗: up to 24 months
次要结局
- number of participants with cardiovascular causes of death(up to 24 months)
- number of participants with re-hospitalization due to cardiovascular causes(up to 24 months)
- number of participants with all causes of mortality(up to 24 months)
- number of participants with non fatal myocardial infarction or stroke(up to 24 months)
- number of participants with myocardial infarction re-exacerbation or re-hospitalization(up to 24 months)
研究者
研究点 (1)
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