Plasma Levels of Micro RNA 203 and 210 Might Spare the Exploratory Laparoscopy in Case of un Explained Infertility With Suspected Endometriosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Benha University
- Enrollment
- 100
- Locations
- 2
- Primary Endpoint
- grading of endometriosis
Study Overview
Brief Summary
The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 30 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •30-45 years old
- •Unexplained infertility
Exclusion Criteria
- •Presence of other causes of infertility,
- •age out of the predetermined range,
- •the presence of immune disorders,
- •maintenance on immunosuppressive drugs
Outcomes
Primary Outcomes
grading of endometriosis
Time Frame: 8 months
The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis
Secondary Outcomes
No secondary outcomes reported
Investigators
Amr Sharaf Eldein
Assistant professor of gynecology
Benha University