Investigation of the skin barrier properties of healthy subjects and atopic eczema patients

Completed

• Conditions: Atopic dermatitis; neurodermitis; 10014982

• Registration Number: NL-OMON33171
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 42

Inclusion Criteria

- Age between 18-40 years
- Caucasian

Exclusion Criteria

- Aged under 18 or over 40;
- Non-Caucasian;
- Abundant hair presence on the upper ventral forearms;
- Unnatural abnormalities on one of their ventral forearms (e.g. skin lesions, tattoos);
- Subjects using any systemic drug therapy (e.g. cholesterol-lowering drugs, insulin related drugs, steroids) or subjects who received phototherapy in the past 2 years.;Additional exclusion criteria for healthy subjects
- No chronically inflammatory disease;
- No dermatological disorders or a history of dermatological disorders;
- No use of dermatological products (e.g. creams) on a daily basis.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Lipid organization by Infrared and Raman spectroscopy and electron<br /><br>diffraction;<br /><br>- Lipid composition by LC/MS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Transepidermal water loss (TEWL)<br /><br>- Water levels in the SC<br /><br>- NMF level in the SC</p><br>