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临床试验/NCT05056285
NCT05056285Unknown不适用

Pattern of Growth and Characteristics of Down Syndrome Pediatrics Patients Attending Assuit University Children Hospital

Assiut University0 个研究点目标入组 50 人开始时间: 2021年10月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
主要终点
The pattern of growth in Down syndrome patients

研究概览

简要总结

Down syndrome or Down's syndrome (DS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45 .

详细描述

People with DS may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue. Other features include: a flat and wide face, a short neck, excessive joint flexibility, extra space between big toe and second toe, abnormal patterns on the fingertips and short fingers. Short stature is a characteristic feature of DS. Growth retardation of DS individuals starts prenatally. After birth, the growth velocity is most reduced between 6 months to 3 years . Growth charts specific for children with DS are important tools for routine medical follow-up, as well as early identification of pathological causes of growth retardation, and monitoring of growth promoting treatments. Growth charts for DS are available from different countries, for example, Italy, USA, Denmark, Sweden, Portugal, France, UK and Ireland and Saudi Arabia .

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Other

入排标准

年龄范围
— 至 4 Years(Child)
性别
All
接受健康志愿者

入选标准

  • All Down syndrome children attending Assuit university less than four years with or without cardiovascular.

排除标准

  • Any Down syndrome child more than four years.

结局指标

主要结局

The pattern of growth in Down syndrome patients

时间窗: 6 months

Descriptive case series study

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Amira Gaber Osman

Amira Gaber Osman

Assiut University

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