Identification of the Physical and Dietary Profile on Constitutionally Lean People: the NUTRILEAN Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anorexia Nervosa
- Sponsor
- University Hospital, Clermont-Ferrand
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Change in energy intake measured during the ad libitum buffet meal (in kcal).
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this study will be to identify the physical and dietary profile of adult women presenting constitutional leanness (CL), comparatively with normal-weight peers and BMI-matched women with anorexia nervosa. After an evaluation of their daily energy intake, physical activity level, body composition, aerobic capacities and muscle strength, women from the normal weight and CL groups will be asked to realized laboratory sessions to evaluate their energy intake and appetite feelings responses to acute exercise
Detailed Description
Body composition (using X-ray absorptiometry), muscle strength (biodex), daily energy intake (dietary record), food preferences (Leeds Food Preference Questionnaire) and physical activity level (GT3X accelerometers) will be assessed among women with constitutional leanness normal weight women and women with anorexia nervosa. The CT and NW groups will then be asked to randomly realized three experimental session: i) a rest session with an fixed lunch meal; a rest session with an ad libitum meal ; iii) an exercise session with an ad libitum meal. Their ad libitum energy intake will be assessed during the two last sessions. Appetite feelings will be assessed at regular intervals and their food reward in response to the lunch will also be assessed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Common criteria to the three groups
- •Aged 18 to 35 years old
- •- Signed consent form
- •being registered in the national social security system
- •no contraindication to physical activity
- •Criteria specific to constitutionally lean women
- •BMI ≤ 17.5 kg/m2
- •Weight stable for the last three months
- •No dietary disorders
- •no sign of denutrition
Exclusion Criteria
- •Pregnancy
- •Intensive physical activity level (aboce 3 sessions per week)
- •Impaired level of IGF-1, estradiol, T3free, cortisol and leptin (for normal weight and constitutionally lean women)
- •Previous surgical interventions that is considered as non-compatible with the study.
- •Medication that could interfer with the study.
- •cardiovascular disease or risks
- •Surgery within the last 3 months
Outcomes
Primary Outcomes
Change in energy intake measured during the ad libitum buffet meal (in kcal).
Time Frame: day 1 , day 8
food intake will be measured ad libitum during a lunch buffet. The participants will be offered an ad libitum buffet-type meal composed based on their food intake preferences. Their intake will be weighted using an electronic food scale by a member of the investigation team and then analysed using Bilnuts software.
Secondary Outcomes
- Physical activity level(day 1)
- change in energy intake measured during the ad libitum buffet meal (in kcal).(day 1 , day 8)
- Body fat mass(day 1)
- fat free mass(day 1)
- Food reward(day 1 , day 8 , day 15)
- Hunger feelings(day 1 , day 8 , day 15)
- Daily energy intake(Trough 3 days)