eural Bases of Subjective Control in Pain Processing

Not Applicable

Recruiting

• Conditions: Pain in healthy participants

• Registration Number: DRKS00029348
• Lead Sponsor: Insitut für Systemische Neurowissenschaften,Universitätsklinikum Hamburg-Eppendorf

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

MRI-safety criteria

Exclusion Criteria

pregnant or nursing, acute or chronic pain, skin injury on arm, acute or chronic somatic or psychiatric illness (based on self-disclosure or professional examination), regular medication intake (except for allergy or thyroid medication, contraceptive medication, occasional use of pain medication), intake of painkillers in the 24 hours preceding the study appointment, symptoms of respiratory illness, contact with a Covid-19 case in the last 14 days

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The present study aims to explore how subjective controllability and expectations affect acute pain perception in healthy subjects. It will examine the extent to which brain activity differs between a) controllable and predictable, b) non-controllable and predictable, and c) non-controllable, non-predictable painful thermal heat stimuli in healthy subjects. Each of the subjects completes all three conditions of the experiment (a-c) in the MRI scanner. The parameters that will be measured with respect to the study goal are the functional brain activation data (fMRI, blood-oxygen-level-dependent response) in the whole brain during the application of thermal pain stimuli, in the above conditions. Additionally, subjective pain ratings will be recorded on a visual analog scale. The analysis will primarily focus on differences in functional brain activation in pain, expectation and controllability related brain areas and subjective pain ratings between conditions. <br> <br>

Secondary Outcome Measures

Name	Time	Method
Exploratory analysis: Computational models to better explain the cognitive mechanisms behind pain ratings of the participants, skin conductance responses, influence of anxiety before experiment, individual differences in controllability sensitivity and locus of control (external vs. internal) as measured with questionnaires. Analysis of fMRI data on single trial basis.