Cortico-spinal interactions underlying pain and pain modulatio
Not Applicable
- Conditions
- eural encoding of opioid-induced analgesia
- Registration Number
- DRKS00021242
- Lead Sponsor
- niversitätsklinikum Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 92
Inclusion Criteria
Healthy, fully competent, male gender, ages between 18 and 45 years, no use of illegal drugs, average alcohol consumption less than 15 glasses per week, cigarette consumption averages less than 20 cigarettes per day
Exclusion Criteria
Chronic pain conditions, acute pain in the last 4 weeks, open injuries, inflammation or skin infections, any long-term medication, participation in another drug-related study in the last 2 months, severe somatic, neurological or psychiatric illness, cancer, alcohol, medication or drug addiction, other serious health problems, current severe mental or physical exertion, hypersensitivity or intolerance to remifentanil, MRI-specific exclusion criteria
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Subjects receive thermal heat stimuli during the MRI experiment, which they should assess on a scale of 0 to 100 with regard to their painfulness. Pain ratings are compared between the groups to investigate how remifentanil in combination with the blinded / open application reduces pain perception compared to NaCl.
- Secondary Outcome Measures
Name Time Method eural activations are compared between the 3 groups, primarily in pain-processing brain regions and in the spinal cord. In addition, the activation in the descending pain system is examined, as well as the connectivity between these areas.